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2015, Number 3

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Acta Med 2015; 13 (3)

Successful use of cyclophosphamide in a case of acute histiocytosis with associated acute hemorrhagic syndrome and progression to multiple organ failure

Mar LTJ, Ibarra GI, Morales CI

Language: Spanish
References: 14
Page: 186-189
PDF size: 148.00 Kb.


ABSTRACT

Histiocytosis is an extremely rare entity characterized by an ineffective immune response and extreme inflammation. It presents with fever, hepatosplenomegaly and cytopenia. The pathognomonic finding is hemophagocytosis. We report the case of a 20-year-old man who started with ecchymotic lesions and gingival bleeding, and evolved to bleeding and shock. He was revived with crystalloids and blood transfusions. He started a conventional treatment, which proved unsuccessful and progressed to ARDS. Cyclophosphamide began as salvage therapy, after which the symptoms subsided. He continued treatment and is currently asymptomatic. Conventional treatment includes dexamethasone, etoposide, cyclosporin and intrathecal methotrexate. This is the first case reported in Mexico successfully treated with this drug.


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