Hütt CE, Brenes DA, Ramírez CB

Language: Spanish
References: 14
Page: 1-7
PDF size: 639.93 Kb.

ABSTRACT

Bagassosis is an interstitial lung disease that forms part of the occupational hypersensitivity pneumonitis. This disease occurs after chronic exposure to particles of moldy pressed cane sugar contaminated with Thermoactinomyces sacchari and Micropolyspora faeni. The pathogenesis of hypersensitivity pneumonitis is not fully understood but is known to have a genetic and environmental basis. It involves both inflammatory and immune responses, with participation of Th1 cells in early stages of the disease and Th2 lymphocytes in later stages. The clinical presentation of this entity has been traditionally classified into acute, sub acute and chronic, depending on the intensity and frequency of exposure to the antigen. Currently, there is no single diagnostic study or biomarker with 100% specificity to diagnose the disease; but rather a variety of diagnostic criteria. Radiologic findings are essential for diagnosis, with computed tomography being the most sensitive and specific study. Bronchoalveolar lavage also plays an important role due to its high specificity. The mainstay of treatment is the elimination of antigen exposure and the use of anti-inflammatory steroids. The prognosis of this disease is very good if diagnosed in the acute phase, but in sub acute and chronic phases the outcome is worse, leading to death in a relatively short period of time.

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