Coll BD, González GF, López LS, González RY

Language: Spanish
References: 11
Page: 489-494
PDF size: 313.44 Kb.

ABSTRACT

Background: ovary granulosa cell tumors represent the 2 to 5 % of all ovary tumors. I t produces steroid hormones with estrogenic or androgynous actions which makes easier its early diagnosis. Two histopathological subtypes are recognized: adult and juvenile.
Objective: to describe the clinical manifestation and histopathological founds in a patient w ith a granulosa cell tumor.
Clinical case: the case of a forty-nine-year-old patient, who clinically presented signs of progressively acquiring male characteristics, is presented. She was diagnosed a tumor in the right ovary by means of a transvaginal ultrasound and a computerized axial tomography. A surgical procedure and a biopsy were conducted; the results of the biopsy confirmed the presence of a granulosa cell tumor.
Conclusions: tumors that produce estrogens are more frequently found and represent the three quarters of the granulosa tumors. Acquiring male characteristics by a granulosa cell tumor in postmenopausal women is infrequent; nevertheless, it was the histopathological diagnosis for this patient.

REFERENCES

1. González JL, Menéndez J, Abela A. Tumor extragonadal de células de la granulosa. Rev Cuba Cir. 2013;52(2):0-0.

2. Pons Porrata LM, García Gómez O, Salmon Cruzata A, Macías Navarro M, Guerrero Fernández CM. Tumores de ovario: patogenia, cuadro clínico, diagnóstico ecográfico e histopatológico. MEDI-SAN. 2012;16(6):0-0.

3. Álvarez Sánchez AC. Correlación ultrasono-gráfica e histopatológica de los tumores de ovario. Rev Cubana Obstet Ginecol. 2010;36(1):0-0.

4. Bachelot A. Hirsutismo: diagnóstico y con-ducta práctica. Tratado de medicina. 2011;15(2):1-6.

5. Cai-Yan Liu. Clinical experience of uterine tumors resembling ovarian sex cord tumors: a clinicopathological analysis of 6 cases. Int J Clin Exp Pathol. 2015;8(4):4158-4164.

6. Blake EA, Sheridan TB, Wang KL, Takiuchi T, Kodama M. Clinical characteristics and outcomes of uterine tumors resembling ovarian sex-cord tu-mors (UTROSCT): a systematic review of litera-ture. Eur J Obstet Gynecol Reprod Biol. 2014;181:163–170.

7. Reverchon M, Cornuau M, Ramé C, Guerif F, Royère D. Chemerin inhibits IGF-1-induced pro-gesterone and estradiol secretion in human granu-losa cells. Hum Reprod. 2012 Jun;27(6):1790-800.

8. D'Angelo E, Mozos A, Nakayama D, Espinosa I, Catasus L. Prognostic significance of FOXL2 mutation and mRNA expression in adult and juve-nile granulosa cell tumors of the ovary. Mod Pathol. 2011 Oct;24(10):1360-7.

9. Kalfa N, Méduri G, Philibert P, Patte C, Boi-zet-Bonhoure B. Unusual virilization in girls with juvenile granulosa cell tumors of the ovary is re-lated to intratumoral aromatase deficiency. Horm Res Paediatr. 2010;74(2):83-91.

10. Corrales Hernández Y, Ayala Reina Z E. Te-ratoma de ovario. Presentación de un caso. Medi-sur 2012;10(2):0-0.

11. Li, Y.K. CT imaging of ovarian yolk sac tu-mor with emphasis on differential diagnosis. Sci Rep. 2015;5:11000.