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2015, Number 3

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Rev Mex Traspl 2015; 4 (3)

Prevalence of corneal graft failure in patients with penetrating keratoplasty

González-Pérez LM, Díaz-Figueroa E, Losada-Floriano D, González-Pérez AF, Lozano-Márquez E

Language: Spanish
References: 18
Page: 103-106
PDF size: 197.45 Kb.


ABSTRACT

Purpose: To determine the prevalence of corneal graft failure in patients undergoing penetrating keratoplasty, and evaluate the related risk factors. Methods: A descriptive, transversal and retrospective study, of patients undergoing penetrating keratoplasty, who presented corneal graft failure, from June 2012 to December 2014, was performed. Results: 1,104 corneal transplants were performed during this period, of which 44 had graft failure. The prevalence of graft failure was 3.8%. With regard to the receptor associated variables, 47.7% of recipients were older than 60, and 29.5% were patients between 40 and 60 years old. The distribution of cases of failure to function preoperative diagnosis was 25% pseudophakic bullous keratopathy, followed by herpetic keratitis (20.5%) and keratoconus (13.6%). The average age of the donor was 31.4 years, and the prevalent cause of death was homicide (75%). All rescued corneas were preserved with Eusol. Conclusions: The prevalence of corneal graft failure in the transplant population is 3.8%. This study found that the most important risk factors for graft failure were pseudophakic bullous keratopathy, post-herpetic keratitis and keratoconus.


REFERENCES

  1. Fuentes-Páez G, Del Castillo-Ruiz A, Naranjo-Tackman R. Opacidad del injerto corneal. Diagnóstico clínico e histopatológico. Rev Mex Oftalmol. 2004; 78 (3): 107-110.

  2. Kamp MT, Fink ME, Enger C, Maguire MC, Stark WJ, Stulting RD. Patient reported symptoms associated with graft reactions in high risk patients in the collaborative corneal transplantation studies. Cornea. 1995; 14 (1): 43-48.

  3. Fasolo A, Frigo AC, Böhm E, Genisi C, Rama P, Spadea L et al; CORTES Group. The CORTES study: corneal transplant indications and graft survival in an Italian cohort of patients. Cornea. 2006; 25: 507-515.

  4. García EE, Pérez A, Acuña A. Consideraciones inmunológicas sobre el rechazo del trasplante de córnea. Rev Cubana Hematol Inmunol Hemoter. 2010; 26 (4): 306-314.

  5. Sugar J, Montoya M, Dontchev M, Tanner JP, Beck R, Gal R et al. Donor risk factors for graft failure in the cornea donor study. Cornea. 2009; 28 (9): 981-985.

  6. Basic and clinical science course. Section 8: External disease and cornea. San Francisco: American Academy of Ophthalmology; 2003.

  7. Price MO, Thompson RW Jr, Price FW Jr. Risk factors for various causes of failure in initial corneal grafts. Arch Ophthalmol. 2003; 121: 1087-1092.

  8. Committee for the Cornea Donor Study Research Group. Factors associated with corneal graft survival in the cornea donor study. JAMA Ophthalmol. 2015; 133 (3): 246-254.

  9. Sit M, Weisbrod DJ, Naor J, Slomovic AR. Corneal graft outcome study. Cornea. 2001; 20 (2): 129-133.

  10. Yu AL, Kaiser M, Schaumberger M, Messmer E, Kook D, Welge-Lussen U. Perioperative and postoperative risk factors for corneal graft failure. Clin Ophthalmol. 2014; 8: 1641-1647.

  11. Guzmán-Jiménez LK, Beauregard-Escobar AM, Ballesteros de la Torre F. Frecuencia de las patologías relacionadas con rechazo a transplante de córnea en pacientes con queratoplastia penetrante. Rev Mex Oftalmol. 2006; 80 (6): 325-329.

  12. Sugar A, Tanner JP, Dontchev M, Tennant B, Schultze RL, Dunn SPet al; Cornea Donor Study Investigator Group. Recipient risk factors for graft failure in the cornea donor study. Ophthalmology. 2009; 116 (6): 1023-1028.

  13. Perera C, Jhanji V, Lamoureux E, Pollock E, Favilla I, Vajpayee RB. Clinical presentation, risk factors and treatment outcomes of first allograft rejection after penetrating keratoplasty in early and late postoperative period. Eye (Lond). 2012; 26: 711-717.

  14. Williams KA, Lowe M, Bartlett C, Kelly TL, Coster DJ. Risk factors for human corneal graft failure within the Australian corneal graft registry. Transplantation. 2008; 86 (12): 1720-1724.

  15. Sugar J, Montoya M, Dontchev M, Tanner JP, Beck R, Gal R et al. Donor risk factors for graft failure in the cornea donor study. Cornea. 2009; 28 (9): 981-985.

  16. Peña RJL, Redel SI, Payahuela DN, Echeverría CS. Trasplante de córnea: perfil epidemiológico y resultados en 9 años de experiencia. CIMEL. 2005; 10: 14-21.

  17. Fernández L, DeWit G, Naranjo R. Prevalencia de falla primaria de queratoplastia penetrante. Rev Mex Oftalmol. 2006; 80 (6): 325-329.

  18. Borderie V, Guilbert E, Touzeau O, Laroche L. Graft rejection and graft failure after anterior lamellar versus penetrating keratoplasty. Am J Ophthalmol. 2011; 151: 1024-1029.




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