2016, Number 2
Sensitivity and specificity of ZAP TnI/ Mio vs Triage Cardiac for the diagnosis of acute myocardial infarction
Full text
Language: Spanish
References: 13
Page: 201-208
PDF size: 575.70 Kb.
ABSTRACT
Background: As cardiovascular disease is now a major cause of morbidity and mortality, the diagnosis of acute myocardial infarction (AMI) should be quick and timely. The performance and diagnostic utility of a qualitative immunochromatographic rapid test helps to significantly reduce morbidity and mortality.Objetive: To determine the sensitivity and specificity of ZAP TnI/Mio vs Triage Cardiac for the diagnosis of AMI.
Material and Method: An observational, descriptive, prospective and transversal study was performed on patients within 3 and 12 hours of a suspected onset of AMI. Data was collected over a period from October 1 to December 31, 2014. Biomarkers troponin I/myoglobin were measured qualitatively and quantitatively. For statistical analysis, χ2 with Yates correction, Fisher's exact test and the Kappa test were used to allow calculation on the degree of agreement.
Results: From the 170 samples that were processed, 107 (63%) were from men and 63 (37%) from women, out of which 100 men and 57 women had elevated troponin I/myoglobin. The mean age was 64 years, χ2 based on the association between rows and columns was observed in the contingency table and considered statistically significant. The ROC curve showed similar sensitivity and specificity in both methods.
Conclusion: Predominance in males with AMI was observed; the mean age was 64 years. The ZAP qualitative test had a sensitivity and specificity similar to the Triage Cardiac test with considerable agreement.
REFERENCES
De Luca G, Suryapranata H, Ottervanger JP, Antman EM. Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction: every minute of Cuadro 2. Cálculo de valores operativos con tabla de contingencia para la prueba cualitativa versus prueba cuantitativa (p <0.05). Concepto Valor Tamaño de muestra Intervalo de confianza (95%) Límite inferior Límite superior Sensibilidad 0.8382 68 0.7962 0.8802 Especificidad 0.9019 102 0.8568 0.9470 Valor predictivo positivo 0.8507 67 0.8081 0.8933 Valor predictivo negativo 0.8932 103 0.8485 0.9379 Razón de verosimilitud positiva 9.2222 8.7510 9.6901 Razón de verosimilitud negativa 0.1792 0.1702 0.1882 c2 con corrección de Yates 0.9054 Kappa 0.7420 delay counts. Circulation 2004; 109(10):1223-1225.