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2016, Number 1

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Dermatología Cosmética, Médica y Quirúrgica 2016; 14 (1)

Treatment of actinic keratoses with daylight photodynamic therapy in 66 patients in Argentina

Passardi SA, Galimberti GN, Galimberti RL
Full text How to cite this article

Language: Spanish
References: 19
Page: 12-16
PDF size: 243.37 Kb.


Key words:

photodamage, methyl aminolevulinate, phototherapy.

ABSTRACT

Daylight mediated photodynamic therapy (TFDLD) is a new treatment virtually painless for the treatment of actinic keratosis (AK) and photodamage in which no incubation time is needed and used as a source of light the sun.
Objetives: to evaluate the effectiveness of treatment for 12 weeks actinic keratosis, the most frequent adverse reactions and patient satisfaction to treatment.
Methodology: from March till June 2015, in the city of Buenos Aires, recruited 66 patients with actinic keratosis grade I, II and III located on the face and scalp. We use 16% methyl aminolevulinate cream that was applied in the treatment area after skin preparation, it was activated by sunlight exposure after two hours outdoors. Actinic keratoses were recorded by type and location prior to treatment and at three months.
Results: in 66 patients a total of 1 573 AK grade I, II and III were treated. Clinically they sent 68% of all treated AK, the response was 82% higher in the AK grade I, grade II then 61% and 24% for grade III. Erythema, scales and crusts were mild and seven days were not present. Patients reported little or no pain during the procedure.
Discussion: TFDLD is a simple and painless for AK varying degrees of treatment, although they have the best answer for grade I and II. It is dependent on the weather and the patient’s adherence to the indications received by the dermatologist.


REFERENCES

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  2. Morton, C., Szeimies, R., Sidoroff, A. y Braathen, L., “European guidelines for topical photodynamic therapy part 1: treatment delivery and current indications actinics keratoses, Bowen’s disease, basal cell carcinoma”, J Eur Acad Dermatol Venerol, 2013, 27: 536-544.

  3. Calzavara-Pinton, Venturini M., “Fototerapia y fotoquimioterapia”, en Giannetti, A. y Galimberti, R., Tratado de dermatología, Roma, Ed. Piccin, 2012, 2583-2587.

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  7. Marecos, R., Galimberti, G., Passardi, S., Galimberti, R. y Guzmán Fawcett, A., “Tratamiento de las queratosis actínicas con terapia fotodinámica con luz de día en Argentina”, DCMQ, 2014, 12 (4): 231–236.

  8. Wiegell, S.R., Haedersdal, M., Eriksen, P. y Wulf, H.C., “Photodynamic therapy of actinic keratoses with 8% and 16% methyl aminolaevulinate and home based daylight exposure: a doublé blinded randomized clinical trial”, Br J Dermatol, 2009, 160: 1308-1314.

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  14. Rubel, D.M. et al., “Daylight photodynamic therapy with methyl aminolevulinate cream as a convenient, similarly effective, nearly painless alternative to conventional photodynamic therapy in actinic keratosis treatment: a randomized controlled trial”, Br J Dermatol, 2014, 171 (5): 1164-1171.

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  16. Lacour, J.P. et al., “Daylight photodynamic therapy with methyl aminolevulinate cream is effective and nearly painless in treating actinic keratoses: a randomized, investigator-blinded, controlled, phase 3 study throughout Europe”, en prensa, JEADV, 2015.

  17. Togsverd-Bo, K., “Combination of ablative fractional laser and daylight mediated photodynamic therapy for actinic keratosis in organ transplant recipients a randomized controlled trial”, Br J Dermatol, 2015, 172 (2): 467-474.

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  19. Wiegell, S.R. et al., “Weather conditions and daylight-mediated photodynamic therapy: protoporphyrin ix-weighted daylight doses measured in six geographical locations”, Br J Dermatol, 2013, 168: 186-191.




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Dermatología Cosmética, Médica y Quirúrgica. 2016;14