>Revista de Investigación Clínica
>Year 2016, Issue 2
Selman M, Buendía-Roldán I, Pardo A
Aging and Pulmonary Fibrosis
Rev Invest Clin 2016; 68 (2)
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Idiopathic pulmonary fibrosis is a chronic, progressive, and usually fatal lung disorder of unknown etiology. The disease likely
results from the interaction of genetic susceptibility architecture, environmental factors such as smoking, and an abnormal
epigenetic reprogramming that leads to a complex pathogenesis. Idiopathic pulmonary fibrosis occurs in middle-aged and
mainly elderly adults, and in this context age has emerged as its strongest risk factor. However, the mechanisms linking it to
aging are uncertain. Recently, nine molecular and cellular hallmarks of aging have been proposed: genomic instability, telomere
attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence,
stem cell exhaustion, and altered intercellular communication. In this review, we provide an overview of these molecular
mechanisms and their involvement in the pathogenesis of idiopathic pulmonary fibrosis, while emphasizing that the studies on
this disease are few and the findings are not definitive.
||Aging, Lung fibrosis, Senescence, Telomeres.
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>Revista de Investigación Clínica
>Year 2016, Issue 2