2016, Number 1
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Rev Mex Cir Endoscop 2016; 17 (1)
Risk factors predictors for complications post-endoscopic retrograde cholangiopancreatography
Langarica ZAM, Hernández RRD, Hernández MC
Language: Spanish
References: 48
Page: 21-28
PDF size: 188.14 Kb.
ABSTRACT
Background: The endoscopic retrograde cholangiopancreatography (ERCP) opened a wide range of diagnostic and therapeutic possibilities for the biliopancreatic pathology, however it has become in the endoscopic technique with the biggest morbi-mortality. Knowing the complications’ risk factors can be used to recognize the high risk patients to develop complications.
Objective: Identify the risk factors related to the complications.
Material and methods: Since January 2014 to February 2015, 70 patients were submitted to ERCP. The complications and variables were determined. We used a bivariated analysis and the multiple logistic regression model to determining association.
Results: The risk factors were: age under 60 years [OR 4.1, CI 95% 0.9-20; p = 0.043]; cannulation in the pancreatic duct [OR 5.6 CI 95% 3.3-9.4; p = 0.018]; diagnostic ERCP [OR 2.2 CI 95% 1.7-2.9; p = 0.034]; difficult to cannulate patients [OR 3.4 CI 95% 3.1-37 p = 0.05]; sphincterotomy [OR 8.6 CI 95% 4.4-16; p = 0.05] and biopsy [OR 13.8 CI 95% 5.9-32; p = 0.006].
Conclusion: Knowing the risk factors can contribute to identify the patients with high risk to develop complications; however a proper selection to the patient will help to diminish the procedure complications.
REFERENCES
ASGE Standards of Practice Committee, Anderson MA, Fisher L, Jain R, Evans JA, Appalaneni V et al. Complications of ERCP. Gastrointest Endosc. 2012; 75: 467-473.
Peñaloza RA, Álvarez CJ. Las complicaciones de la CPRE: una mirada a la evidencia local. Rev Col Gastroenterol. 2010; 25: 338-340.
González-Huezo MS, Jeréz-González L, Bobadilla-Díaz J, Robles-Díaz G, Uscanga L. Colangiografía endoscópica en pancreatitis aguda biliar leve: cuándo y a quién. Rev Gastroenterol Mex. 2002; 67: 87-92.
Yriberry SU, Salazar F, Monge V, Prochazka R, Vila S, Barriga JA et al. Eventos adversos esperados e inesperados en la endoscopía terapéutica de la vía biliar (CPRE): experiencia en un Centro Privado Nacional con 1,356 casos consecutivos (1999-2008). Rev Gastroenterol Perú. 2009; 29: 311-320.
Güitrón-Cantú A, Adalid-Martínez R, Gutiérrez-Bermúdez JA, Nieves-Rentería A, Álvarez-Valdés G. Complicaciones en colangiopancreatografía endoscópica diagnóstica y terapéutica. Estudio prospectivo. Rev Gastroenterol Mex. 2007; 72: 227-235.
Olazábal EA, Brizuela RA, Roque R, Barrios I, Quintana I, Sanchez EC. Complicaciones de la colangiopancreatografía retrógrada endoscópica en las urgencias digestivas. Revista Habanera de Ciencias Médicas. 2011; 10: 465-475.
Quispe A, Sierra W, Callacondo D, Torreblanca J. Factores asociados a complicaciones de la colangiopancreatografía retrógrada endoscópica en un hospital de alta complejidad. Rev Perú Med Exp Salud Publica. 2010; 27: 201-208.
Freeman ML, Guda NM. Prevention of post-ERCP pancreatitis: a comprehensive review. Gastrointest Endosc. 2004; 59: 845-864.
Ruiz J, Brizuela RA, Martinez R, Diaz O, Pernia L. Esfinterotomía endoscópica y litiasis biliar. Gen [online]. 2010; 64: 186-189.
Reyes-Moctezuma GA, Suárez-Peredo LS, Reyes-Bastidas MR, Ríos-Ayala MA, Rosales-Leal JE, Osuna-Ramírez I. Colangiografía retrógrada endoscópica en un hospital regional del IMSS 2002-2011: factores de riesgo y complicaciones. Rev Gastroenterol Méx. 2012; 77: 125-129.
Colton JB, Curran CC. Quality indicators, including complications, of ERCP in a community setting: a prospective study. Gastrointest Endosc. 2009; 70: 457-467.
Masci E, Toti G, Mariani A et al. Complications of diagnostic and therapeutic ERCP: a prospective multicenter study. Am J Gastroenterol. 2001; 96: 417-423.
Loperfido S, Angelini G, Benedetti G et al. Major early complications from diagnostic and therapeutic ERCP: a prospective multicenter study. Gastrointest Endosc. 1998; 48: 1-10.
Gomez M, Delgado L, Arbeláez V. Factores de riesgo asociados a pancreatitis e hiperamilasemia postcolangiopancreatografía retrógrada endoscópica (CPRE). Rev Col Gastroenterol. 2012; 27: 7-20.
Etzel JP, Eng SC, Ko CW, Lee SD, Saunders MD, Tung BY et al. Complications after ERCP in patients with primary sclerosing cholangitis. Gastrointest Endosc. 2008; 67: 643-648.
Artifon EL, Tchekmedyian AJ, Aguirre AP. Colangiopancreatrografía retrógrada endoscópica: una técnica en permanente evolución. Rev Gatroenterol Peru. 2013; 33: 321-327.
Das A, Singh P, Sivak MV Jr et al. Pancreatic-stent placement for prevention of post-ERCP pancreatitis: a cost-effectiveness analysis. Gastrointest Endosc. 2007; 65: 960-968.
Aldana GE, Betancourt AP. Perforación duodenal postcolangiopancreatografía retrógrada endoscópica. Repert Med Cir. 2008; 17: 145-155.
Miller R, Zbar A, Klein Y, Buyeviz V, Melzer E, Mosenkis B et al. Perforations following endoscopic retrograde cholangiopancreatography: a single institution experience and surgical recommendations. Am J Surg. 2013; 206: 180-186.
Huguet J, Sempere J, Bort I, Canelles P, Rodriguez E, Durá AB et al. Complicaciones de la colangiopancreatografía retrógrada endoscópica en pacientes mayores de 90 años. Gastroenterol Hepatol. 2005; 28: 263-266.
Ávila JA, Montaño A, Zepeda S, Meza J, Melano E, Valdovinos F et al. Endoscopic retrograde cholangiopancreatography in the elderly. Rev Invest Clin. 2005; 57: 666-670.
Gómez ZM, Melgar C, Arbeláez V. ¿Es la edad un factor que incide en las complicaciones por cpre? Rev Col Gastroenterología. 2010; 25: 349-353.
Freeman ML, Nelson DB, Sherman S et al. Complications of endoscopic biliary sphincterotomy. N Engl J Med. 1996; 335: 909-918.
Montaño A, Rodriguez JE, Garcia C, Davalos G, Cervantes F et al. Efecto de la administración de indometacina rectal sobre los niveles séricos de amilasa posteriores a colangiopancreatografía retrógrada endoscópica y su impacto en la aparición de episodios de pancreatitis secundaria. Rev Esp Enferm Dig. 2007; 99: 330-336.
Mazaki T, Masuda H, Takayama T. Prophylactic pancreatic stent placement and post-ERCP pancreatitis: a systematic review and metaanalysis. Endoscopy. 2010; 42: 842-853.
Cotton PB, Lehman G, Vennes J, Russell RC, Meyers WC et al. Endoscopic sphinterotomy complicattions and their management: an attempt at consensus. Gastrointest Endosc. 1991; 37: 383-393.
Rábago L, Guerra I, Moran M, Quintanilla E, Collado D, Chico I et al. Is outpatient ERCP suitable, feasible, and safe? The experience of a Spanish community hospital. Surg Endosc. 2010; 24: 1701-1706.
Christoforidis E, Goulimaris I, Kanellos I, Tsalis K, Demetriades C, Betsis D. Post ERCP pancreatitis and hyperamilasemia: patient related and operative risk factors. Endoscopy. 2002; 34: 286-292.
Freeman ML, Nelson DB, Sherman S, Haber HG. Complications of endoscopic biliary schinterotomy. N Engl J Med. 1996; 335: 909-918.
Guidi M, Jer H, Curvale C, Souto G, De Maria J, Ragone F et al. Calidad y competencia en colangiografía endoscópica. Rumbo a lo seguro. Acta Gastroenterol Latinoam. 2015; 45: 37-45.
Cooper ST, Slivka A. Incidence, risk factors, and prevention of post-ERCP pancreatitis. Gastroenterol Clin North Am. 2007; 36: 259-276.
Jowell PS, Baillie J, Branch MS et al. Quantitative assessment of procedural competence: a prospective study of training in endoscopic retrograde cholangiopancreatography. Ann Intern Med. 1996; 125: 983-989.
Petersen BT. ERCP outcomes: defining the operators, experience, and environments. Gastrointest Endosc. 2002; 55: 953-958.
Freeman ML, DiSario JA, Nelson DB, Fennerty MB, Lee JG, Bjorkman DJ et al. Risk factors for post-ERCP pancreatitis: a prospective, multicenter study. Gastrointest Endosc. 2001; 54: 425-434.
Jeurnink SM, Poley JW, Steyerberg EW, Kuipers EJ, Siersema PD. Endoscopic retrograde cholangiopancreatography as an outpatient treatment: a review. Gastrointest Endosc. 2008; 68: 118-123.
Christensen M, Matzen P, Schulze S, Rosenberg J. Complications of ERCP: a prospective study. Gastrointest Endosc. 2004; 60: 721-731.
Friedland S, Soetikno RM, Vandervoort J, Montes H, Tham T, Carr-Locke DL. Bedside scoring system to predict the risk of developing pancreatitis following ERCP. Endoscopy. 2002; 34: 483-488.
Jeurnink SM, Siersema PD, Steyerberg EW, Dees J, Poley JW, Haringsma J et al. Predictors of complications after endoscopic retrograde cholangiopancreatography: a prognostic model for early discharge. Surg Endosc. 2011; 25: 2892-2900.
Mehta SN, Pavone E, Barkun JS, Bouchard S, Barkun AN. Predictors of post-ERCP complications in patients with suspected choledocholithiasis. Endoscopy. 1998; 30: 457-463.
Masci E, Mariani A, Curioni S, Testoni PA. Risk factors for pancreatitis following endoscopic retrograde cholangiopancreatography: a meta-analysis. Endoscopy. 2003; 35: 830-834.
Cheng CL, Foliente RL, Santoro MJ, Walter MH. Risk factors for post ERCP pancreatitis: a prospective multicenter study. Am J Gastroenterol. 2006; 101: 139-147.
Gottlieb K, Sherman S. ERCP and biliary endoscopic sphincterotomy-induced pancreatitis. Gastrointest Endosc Clin N Am. 1998; 8: 87-114.
Cotton PB, Garrow DA, Gallagher J, Romagnuolo J. Factores de riesgo para complicaciones posteriores a colangio pancreatografía retrógrada endoscópica: análisis multivariado de 11,497 procedimientos en 12 años. Gastrointest Endosc. 2009; 70: 89-91.
Kawai K, Akasaka Y, Murakami K et al. Endoscopic sphincterotomy of the ampulla of Vater. Gastrointest Endosc. 1974; 20: 148-151.
Sherman S, Ruffolo TA, Hawes RH, Lehman GA. Complications of endoscopic sphincterotomy. A prospective series with emphasis on the increased risk associated with non dilated bile ducts. Gastroenterology. 1991; 101: 1068-1075.
Rabenstein T, Schneider HT, Bulling D, Nicklas M, Katalinic A, Hahn EG et al. Analysis of the risk factors associated with endoscopic sphincterotomy techniques: preliminary results of a prospective study, with emphasis on the reduced risk of acute pancreatitis with low-dose anticoagulation treatment. Endoscopy. 2000; 32: 10-19.
Vandervoort J, Soetikno RM, Tham TC, Wong RC, Ferrari AP Jr, Montes H et al. Risk factors for complications after performance of ERCP. Gastrointest Endosc. 2002;56: 652-656.
Boender J, Nix GA, Ridder MA, Van Blankenstein M. Endoscopic papillotomy for common bile duct stones: factors influencing the complication rate. Endoscopy. 1994; 26: 209-216.