Urbina ME

Language: Spanish
References: 11
Page: 491-496
PDF size: 328.58 Kb.

ABSTRACT

Zollinger-Ellison syndrome (ZES) is a condition characterized by gastrinsecreting tumors, responsible for causing the formation of multiple, refractory, and recurrent peptic ulcers in the duodenum. Two main variants have been described, sporadic and those found in association with multiple endocrine neoplasia-1 (MEN- 1). Biochemical serum evaluation for elevated gastrin, followed by radiological or nuclear localization of the primary lesion, is mandated for establishing diagnosis. The mainstays of treatment include management of hypersecretory state with medical suppression of gastric acid production and surgical resection of primary tumor for the prevention of malignant transformation and metastatic complications. Medical therapy with proton pump inhibitors has virtually eliminated the need for acidreducing surgical procedures. Reexcision of recurrent or resection of metastatic disease is a subject of controversy; however, at the present time aggressive cytoreductive approach is favored.

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