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Archivos de Investigación Materno Infantil

ISSN 2007-3194 (Print)
Órgano de difusión oficial del Instituto Materno Infantil del Estado de México
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2015, Number 3

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Arch Inv Mat Inf 2015; 7 (3)

Virilization secondary to ovarian hyperandrogenism in Van Wyk-Grumbach syndrome: a case report

Moreno-Guzmán LS, Sandoval-Benítez M, Núñez-Hernández JA, Sánchez-Castillo JL
Full text How to cite this article

Language: Spanish
References: 6
Page: 104-106
PDF size: 136.78 Kb.


Key words:

Van Wyk-Grumbach syndrome, acquired hypothyroidism, ovarian hyperandrogenism.

ABSTRACT

Van Wyk-Grumbach syndrome was first described in 1960 and its frequency is unknown; it is characterized by hypothyroidism, delayed bone age and precocious puberty of the same sex, with reversion to a prepuberal state after replacement therapy of the thyroid hormone. We report the case of a patient with acquired hypothyroidism, ovarian hyperandrogenism.


REFERENCES

  1. Van Wyk JJ, Grumbach MM. Syndrome of precocious menstruation and galactorrhea in juvenile hypothyroidism. An example of hormonal overlap in pituitary feedback, J Pediatr, 1960; 57: 416-435.

  2. Rastogi A, Bhadada SK, Bhansali A. An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome, Indian J Endocinol Metab, 2011; 15 (Suppl 2): S141-S143.

  3. Shivaprasad KS, Dutta D, Jain R, Kumar M, Maisnam I, Biswas D et al. Huge bilateral ovarian cysts in adulthood as the presenting feature of Van Wyk Grumbach syndrome due to chronic uncontrolled juvenile hypothyroidism, Indian J Endocrinol Metab, 2013; 17 (Suppl 1): S164-S166.

  4. Iqbal MZ, Saleem M, Shahzad ZA. A case of Van Wyk-Grumbach syndrome, APSP J Case Rep, 2013; 4 (2): 24.

  5. Zhang H, Geng N, Wang Y, Tian W, Xue F. Van Wyk and Grumbach syndrome: two case reports and review of the published work, J Obstet Gynaecol Res, 2014; 40 (2): 607-610.

  6. Baranowski E, Högler W. An unusual presentation of acquired hypothyroidism: the Van Wyk-Grumbach syndrome, Euro J Endocrinol 2012; 166 (3): 537-542.




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Arch Inv Mat Inf. 2015;7