2016, Number 2
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ABSTRACTThe presence of protein in urine is called proteinuria in adults is clinically defined by a urinary excretion of more than 150 mg in 24 hours and proteins occurs by a change in the glomerular filtration barrier, which allows the escape of proteins in urine. Proteinuria is common in various diseases, particularly monoclonal gammopathies. The criteria for diagnosis of these entities include the presence of abnormal plasma cells in the bone marrow, a monoclonal protein increased serum, a monoclonal protein in urine or osteolytic lesions. For diagnosis, evaluation and treatment monitoring of monoclonal gammopathies, electrophoretic studies proteins plasma or serum and urinary proteinograms technique that allows separation of proteins based on their differential migration when subjected to an electric field is performed.
Joly D, Choukroun G, Combe C, Dussol B, Fauvel JP, Halimi JM, et al. Glycemic control according to glomerular filtration rate in patients with type 2 diabetes and overt nephropathy: A prospective observational study. Diabetes Res Clin Pract. 2015 Apr;108(1):120-7. doi: 10.1016/j.diabres.2015.01.029.
Zamora-Ortiz G, Velázquez-Sánchez-de-Cima S, Hernández-Reyes J, Martagón- Herrera NA, Ruiz-Argüelles A, Ruiz-Delgado GJ, et al. Poor performance of the total kappa/lambda light chain quantification in the diagnosis and follow-up of patients with multiple myeloma. Rev Invest Clin. 2014 Jul-Aug;66(4):314-8.
Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, et al. International Kidney and Monoclonal Gammopathy Research Group Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant. Blood. 2012 Nov 22; 120(22):4292-5. doi: 10.1182/blood-2012-07- 445304.
Faiman BM, Mangan P, Spong J, Tariman JD, The International Myeloma Foundation Nurse Leadership Board . Renal complications in multiple myeloma and related disorders: survivorship care plan of the International Myeloma Foundation Nurse Leadership Board. Clin J Oncol Nurs. 2011 Aug; 15 Suppl:66-76. doi: 10.1188/11