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2005, Number 1

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Med Int Mex 2005; 21 (1)

Onion consumption as an adjuvant in glycemic control of type 2 diabetes

López II, Lozano NJJ, Jiménez SNG, Rubio GAF
Full text How to cite this article

Language: Spanish
References: 10
Page: 44-51
PDF size: 56.18 Kb.


Key words:

diabetes mellitus type 2, glycemic control, onion consumption.

ABSTRACT

Background: Some researchers have carried out studies in animals and diabetic people, where they have found that the onion (Allium cepa Linn) reduces serum glucose levels. This is due to the allyl propyl disulphide (C3HS-SC3H7) found in the bulb of the onion.
Objective: To know the significant effect of the consumption of raw onion on the serum glucose levels as an auxiliary treatment in patients with diabetes mellitus type 2 treated with oral hypoglycemic agents.
Material and methods: A controlled clinical study that included 105 diabetic type 2 patients, with an age range from 30 to 75 years old, 5 years of diagnosis as the most, with blood glucose between 80 and 210 mg/dL and who were in treatment with oral hypoglycemic agents was carried out in the external consultation of the Ticomán General Hospital. There were two groups, one formed by 52 patients who were given 100 g of white raw and milled onion in fast, besides their pharmacological treatment; and other group of 53 patients who only took pharmacological treatment. The follow-up lasted three months, and every month a control of serum glucose in fast was taken.
Results: The average value of blood glucose in the group of patients with onion consumption was from 161.8 mg/dL at the beginning of the study, of 155.6, 162.3, and 151.7 mg/dL in the first, second and third month of follow-up, while in the group without onion consumption was of 164.9 mg/dL of initial glucose, and of 192.5, 173.4, and 182.7 mg/dL during the three next months, respectively. The t Student test was applied in the three months. In the first month we obtained 6.01 p ‹ 0.05, in the second 1.60 p › 0.05, and in the third one 5.78 p ‹ 0.05. 10 infections of the urinary tract were presented in the second month, five in each group.
Conclusions: The consumption of 100 g of raw onion in fast, as an auxiliary in the treatment of diabetic patients type 2 treated with oral hypoglycemic agents, produced a significant decrease of blood glucose in the first and third month, in relation to the patients that did not consume it. This was not seen in the second month.


REFERENCES

  1. Augusti KT, Semple M, Roy VC. Effect of allyl propyl disulphide isolated from onion (Allium cepa L.) on glucose tolerance of alloxan diabetic rabbits. Experientia 1974;10:1119-20.

  2. Babu PS, Srinivasan K. Influence of dietary capsaicin and onion on the metabolic abnormalities associated with streptozotocin induced diabetes mellitus. Mol Cell Biochem 1997;175:49-57.

  3. Sharma KK, Gupta RK, Samuel KC. Antihyperglycemic effect of onion: effect on fasting blood sugar and induced hyperglycemia in man. Indian J Med Res 1977;65:422-9.

  4. Augusti KT, Benaim ME. Effect of essential oil of onion on blood glucose, free fatty acid and insulin levels of normal subjects. Clin Chim Acta 1975;60:121-3.

  5. Kumari K, Mathew BC, Augusti KT. Antidiabetic and hypolipidemic effects of S-methyl cysteine sulfoxide isolated from Allium cepa Linn. Indian J Biochem Biophys 1995;32(1):49-54.

  6. Augusti KT, Brahmachari HD. Hypoglycaemic agents from indian indigenous plants. J Pharm Pharmacol 1962;14:254-5.

  7. Augusti KT. Effect on allyl propyl disulphide obtained from onion. Naturwissenschaften 1974;61:173-4.

  8. Augusti KT. Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats. Planta Med 1995;61:356-7.

  9. Sanchez-Hernández MC, Hernández M, Delgado J, et al. Allergenic cross-reactivity in the Liliaceae family. Allergy 2000;55(3):297-9.

  10. Tjkropraviro A, Pikir BS, Soewondo H, et al. Metabolic effects of onion and green beans on diabetic patients. Tohoku J Exp Med 1983;141(S1):671-6.




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Med Int Mex. 2005;21