2016, Number 1-2
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Rev Mex Med Fis Rehab 2016; 28 (1-2)
Gait analysis in patients with Duchenne muscular dystrophy with functional level 2, 3 and 4 on the scale of Vignos
Pérez-Moreno JC, Madrigal-Morales R, Torres-Olmos C, Villanueva-Ayala D
Language: Spanish
References: 21
Page: 19-27
PDF size: 657.92 Kb.
ABSTRACT
The natural history of Duchenne muscular dystrophy is the gait impairment characterized by progressive wasting of proximal muscles, increase in the endeavor to walking and final dependency of wheelchair towards the ten years of age.
Objective: To analyze the gait kinematic in patients with Duchenne muscular dystrophy in stage 2, 3 and 4 of Vignos Scale.
Method: Six patients between 3 to 11 years of age were included. Three-dimensional gait analysis included temporary-spatial parameters, kinematic and ground reaction forces.
Results: The average cadence was 123.5 ± 6.36 steps per minute; velocity mean was 0.69 ± 0.08 m/s. The kinematic of hip, knee and ankle showed differences in the peaks of flexion and extension in patients over ten years and these were independent of Vignos stage. Ground reaction forces exhibited decrease in the magnitude of vertical force in all patients.
Conclusion: The phase 4 of Vignos functional scale was the most critical stage of gait in patients with Duchenne muscular dystrophy because the changes in kinematics are determinants in the illness progression.
REFERENCES
Emery AH. Population frequencies of inhered neuromuscular diseases-a world survey. Neuromuscul Disord. 1991; 1(1): 19-29.
Bushby K, Finkel R, Birnkrant DJ, Case LE, Clemens PR, Cripe L et al. Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management. Lancet Neurol. 2010; 9(1): 77-93.
Kottlors M, Kirschner J. Elevated satellite cell number in Duchenne muscular dystrophy. Cell Tissue Res. 2010; 340(3): 541-548.
Davis KE, Nowak KJ. Molecular mechanisms of muscular dystrophies: old and new players. Nat Rev Mol Cell Biol. 2006; 7(10): 762-773.
Aartsma-Rus A, Ginjaar IB, Bushby K. The importance of genetic diagnosis for Duchenne muscular dystrophy. J Med Genet. 2016; 53(3): 145-151.
López-Hernández LB, van Heusden D, Soriano UMA, Figuera VL, Vazquez CNA, Canto P et al. Genotype-phenotype discordance in a Duchenne muscular dystrophy patient due to a novel mutation: insights into the shock absorber function of dystrophin. Rev Neurol. 2011; 52(12): 720-724.
Menkes JH, Sarnat HB. Child neurology. 6th ed. Lippincott Williams & Wilkins; 2006.
Bakker JP, De Groot IJ, Beelen A, Lankhorst GJ. Predictive factors of cessation of ambulation in patients with Duchenne muscular dystrophy. Am J Phys Med Rehabil. 2002; 81(2): 906-912.
Engel AG, Franzini C. Myology Vol. 2. 2d ed. International Edition McGraw-Hill; 1994.
Chang RF, Mubarak SJ. Pathomechanics of Gowers’ Sign. A Video Analysis of a Spectrum of Gowers’ Maneuvers. Clin Orthop Relat Res. 2012; 470(7): 1987-1991.
Vignos PJ, Spencer GE, Archibald KC. Management of progressive muscular dystrophy of childhood. JAMA. 1963; 184: 89-96.
Sutherland DH, Olshen R, Cooper L, Wyatt M, Leach J, Mubarak S et al. The pathomechanics of gait in Duchenne muscular dystrophy. Dev Med Child Neurol. 1981; 23(1): 3-22.
Doglio L, Pavan E, Pernigotti I, Petralia P, Frigo C, Minetti C. Early signs of gait deviation in Duchenne muscular dystrophy. Eur J Phys Rehabil Med. 2011; 47(4): 587-594.
D’Angelo MG, Berti M, Piccinini L, Romei M, Guglieri M, Bonato S et al. Gait pattern in Duchenne muscular dystrophy. Gait Posture. 2009; 29(1): 36-41.
Gaudreault N, Gravel D, Nadeau S, Houde S, Gagnin D. Gait patterns comparison of children with Duchenne muscular dystrophy to those of control subjects considering the effect of gait velocity. Gait Posture. 2010; 32(3): 343-347.
Moxley RT 3rd, Ashwal S, Pandya S et al. Practice Parameter: Corticosteroid treatment of Duchenne dystrophy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2005; 64(1): 13-20.
Davis RB, Ounpuu S, Tybursky D, Gage JR. A gait analysis data collection and reduction technique. Hum Mov Sci. 1991; 10: 575-587.
Moreno HA, Rodríguez RG, Quiñones UI, Núñez CL, Pérez SAI. Temporal and spatial gait parameters analysis in non-pathological Mexican children. Gait Posture. 2010; 32(1): 78-81.
Holm I, Tveter AT, Fredriksen PM, Vøllestad N. A normative sample of gait and hopping on one leg parameters in children 7-12 years of age. Gait Posture. 2009; 29(2): 317-321.
Medical Research Council of the UK. Aids to the investigation of Peripheral Nerve Injuries. Memorando No. 45. London, Pendragon House 1976; 6-7.
Kirtley C. Clinical gait analysis. Theory and Practice. Churchill Livingstone Elsevier; 2006.