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Academia Mexicana de Neurología, A.C.

2016, Number 3

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Rev Mex Neuroci 2016; 17 (3)

Neuropsychological characterization of ADHD with anxiety, and its association of single-nucleotide polymorphisms of the DGKH gene in a pediatric population

Polanco-Barreto ÁM, Arboleda-Bustos H, Pinto MC, Ávila JE, Vásquez R

Language: Spanish
References: 39
Page: 39-48
PDF size: 154.16 Kb.


ABSTRACT

Introduction: The attention deficit hyperactivity disorder (ADHD) is one of the most frequent psychiatric disorders in children. It has been identified that 60% of patients have comorbidity with other disorders such as learning disorders, anxiety, affective disorders, tics, obsessivecompulsive disorders, and other behavior. The presence of polymorphisms of the DGKH gene has been described in affective disorders, schizophrenia and ADHD, becoming a focus of attention in the analysis of the functioning of some prefrontal mechanisms.
Objective: To conduct a neuropsychological characterization of comorbid ADHD patients with anxiety disorder (AD) and to explore a possible association of two common polymorphisms (rs1170169 and rs9525580) of DGKH gene, in a sample of school children and adolescents from Colombia.
Material and methods: A total of 30 diagnosed cases with ADHD and AD were included, as well as 29 patients with ADHD without comorbidity and 33 controls. For the association of polymorphisms, the technique used was a standard PCR and the respective analyzes were performed through bioinformatics and statistical methods.
Results: Children diagnosed with comorbid ADHD with AD had a low cognitive performance globally. This difference is significant, compared to the group without comorbidity and the control group. The single nucleotide polymorphism (SNP) rs1170169 was found to be significantly protective for patients with comorbid ADHD with AD as well as for the AD group without the disorder (OR: 0.39, 95% CI: 0.198–0.6873; p=0.01097). On the other hand, we identified that the gene variant rs9525580 was associated with ADHD without comorbidity, as compared with controls (OR: 2.5, 95% CI: 1.191–5.248; p=0.01).
Conclusions: Common gene polymorphisms of the DGKH gene may be associated with both ADHD and ADHD with comorbidities phenotypes. This study adds to the understanding of geneenvironment relationship in children with ADHD.


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