Belli MHR, Cauich EE, Cih OGA, Ruiz GJ, Jiménez BMV

Language: Spanish
References: 11
Page: 116-124
PDF size: 643.45 Kb.

ABSTRACT

Introduction: Castleman disease (CD) is a rare entity characterized by non-tumoral proliferation of lymphatic tissue, that occurs with equal frequency in both sexes and at any age, however, it prevails between the third and fifth decade of life. There is no histological evidence of direct involvement to the central nervous system (CNS); however, it has ben demonstrated the presence of masses and infiltration of the leptomeninges, as well as myasthenia gravis, dysarthria, aphasia, epileptic seizure and coma.
Case report: A 51-year-old male arrived to the emergency room with a two-weeks history of left hemiparesis. The patient was evaluated by the Neurology service, and an angio-MRI showed right internal carotid artery occlusion and multiple infarcts possibly secondary to Castleman disease, associate with right leptomeningitis. The patient was initiated on deflazacort, statins, antiplatelets and physical rehabilitation achieving progressive improvement.
Conclusion: The prognosis of the disease is serious without treatment. The most frequent causes of death in these patients are infections, renal insufficiency and malignancies.

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