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ISSN 0016-3813 (Print)

2016, Number 6

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Gac Med Mex 2016; 152 (6)

Comparison of peak oxygen uptake and VE/VCO2 slope, between children with and without heart failure

Ilarraza-Lomelí H, Miranda CI, Castañeda-López J, Chávez-Domínguez R, Barrera-Ramírez CF, García-Saldivia M, Rius-Suárez MD, Buendía-Hernández A

Language: Spanish
References: 16
Page: 734-740
PDF size: 106.38 Kb.


ABSTRACT

Heart failure is a health problem associated with disability and mortality. Physicians may stratify the risk of adult patients with heart failure using a cardiopulmonary exercise testing. Until now, in childhood this evaluation has been poorly used. The purpose of this study is to compare the peak oxygen uptake and minute ventilation/carbon dioxide production slope among children with heart failure versus children without heart disease (control). Methods: Thirty-eight children with heart failure were compared with 194 children without heart disease. All of them performed cardiopulmonary exercise testing using a symptom-limited ramp protocol. Differences between groups were compared using Chi-squared test, Student’s t test, or ANOVA. Any value of p ‹ 0.05 was considered significant. Results: Children with heart failure were older, taller, and with a higher prevalence of male gender. This group had also a lower peak oxygen uptake (27 ± 10 ml O2/kg/min) compared to the control group (37 ± 10 ml O2/kg/min); p ‹ 0.001. The minute ventilation/carbon dioxide production was higher in the heart failure group (31 ± 4) than in controls (28 ± 6); p ‹ 0.001. Conclusion: Children with heart failure showed lower peak oxygen uptake and higher minute ventilation/carbon dioxide production slope than the control group.


REFERENCES

  1. Puigbó JJ. La fragua de la medicina clínica y de la cardiología. Consejo de Desarrollo Científico y Humanístico. Fundación Polar. Caracas, Venezuela; 2002.

  2. Braunwald E. The management of heart failure: the past, the present, and the future. Circ Heart Fail. 2008;1:58-62.

  3. McMurray J, Adamopoulos S, Anker S, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Eur Heart J. 2012;33:1787-847.

  4. Hsu D, Pearson G. Heart failure in children. Part I: History, etiology, and pathophysiology. Circ Heart Fail. 2009;2:63-70.

  5. Giardini A, Fenton M, Andrews R, Derrick G, Burch M. Peak oxygen uptake correlates with survival without clinical deterioration in ambulatory children with dilated cardiomyopathy. Circulation.2011;124:1713-8.

  6. Hsu D, Pearson G. Heart failure in children: Part II: Diagnosis, treatment, and future directions. Circ Heart Fail. 2009;2:490-8.

  7. Froelicher V, Myers J. Exercise and the heart. 5th ed. Philadelphia: Saunders; 2006.

  8. Weisman I, Marciniuk D, Martinez F, Sciurba F, Sue D, Myers J. ATS/ ACCP Statement on cardiopulmonary exercise testing. II. Indications for cardiopulmonary exercise testing. Am J Respir Crit Care Med. 2003; 167:211-77.

  9. Guazzi M. Abnormalities in cardiopulmonary exercise testing ventilatory parameters in heart failure: pathophysiology and clinical usefulness. Curr Heart Fail Rep. 2014;11:80-7.

  10. Mann DL, Bristow MR. Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation. 2005;111:2837-49.

  11. Ilarraza-Lomelí H, Castañeda-López J, Myers J, et al. Cardiopulmonary exercise testing in healthy children and adolescents at moderately high altitude. Arch Cardiol Mex. 2013;83:176-82.

  12. Paridon SM, Alpert BS, Boas SR, et al. Clinical stress testing in the pediatric age group: a statement from the American Heart Association Council on Cardiovascular Disease in the Young, Committee on Atherosclerosis, Hypertension, and Obesity in Youth. Circulation. 2006;113: 1905-20.

  13. Barbosa O, Ribeiro L, Sobral D. Treadmill stress test in children and adolescents: higher tolerance on exertion with ramp protocol. Arq Bras Cardiol. 2007;89:354-9.

  14. Ilarraza-Lomelí H. Prueba de ejercicio con análisis de gases espirados. Arch Cardiol Mex. 2012;82:160-9.

  15. Webster G, Zhang J, Rosenthal D. Comparison of the epidemiology and co-morbidities of heart failure in the pediatric and adult populations: a retrospective, cross-sectional study. BMC Cardiovasc Disord. 2006;6:23.

  16. Guimarães GV, d’Avila VM, Camargo PR, Moreira LF, Lanz JR, Bocchi EA. Prognostic value of cardiopulmonary exercise testing in children with heart failure secondary to idiopathic dilated cardiomyopathy in a non- -beta-blocker therapy setting. Eur J Heart Fail. 2008;10:560-5




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