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2016, Number 4

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Rev Hematol Mex 2016; 17 (4)

Sideroblastic anemia

Ramírez-Izcoa A, Díaz-Valle D, Chiang-Alvarado E, Fu-Carrasco L, Sabio H

Language: Spanish
References: 13
Page: 287-292
PDF size: 348.11 Kb.


ABSTRACT

Sideroblastic anemia is a heterogeneous group of disorders that can be inherited or acquired characterized by a pathological overload of iron deposits in the perinuclear mitochondria of the erythroblasts, thus forming a partial or complete ring around the core forming the so-called ring sideroblasts in the bone marrow. This paper reports the case of a currently 10-year-old male patient who was referred to the service of pediatric hematooncology at 3 months of age by presenting microcytic anemia without deficiency of iron, folate nor vitamin B12. Bone marrow aspirate reported aplasia of the red cells, blasts, relationship erythroid myeloid 1:2; treated since then with steroids but the response to treatment was not observed. At 7 years of age a second bone marrow aspirate was performed with the application of blue staining Prussia which reported a positive result with the presence of ring sideroblasts, currently with adequate growth and development for his age, treated with chelation of iron, pyridoxine and chronic blood transfusions with periodic evaluation of iron tissue accumulation. The report of this case demonstrates the importance of a good trial of the patient and the appropriate laboratory correlation to a timely and successful diagnosis, allowing effective treatment and thus reducing the possible complications, consequently improving life quality.


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