2017, Number 1
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ABSTRACTIntroduction: the drepanocytosis is a disease with multisystem impact. Renal disease begins in childhood and chronic consequences are glomerulopathy sickle glomerular with evolution to chronic renal failure. Objective: to know how renal disorders are expressed in pediatric patients with drepanocytosis. Method: a prospective descriptive study was realized in pediatric patients with drepanocytosis attended in the outpatient of Hematology at “José Luis Miranda” Hospital between August 2013 and December 2014. Sixteen asymptomatic patients were included in the last month without transfused in the previous three months. Clinical variables, hematological, biochemical and imaging were evaluated in order to describe the renal abnormalities. Results: three patients with positive microalbuminuria were diagnosed; the average age was 13 years, the hemoglobinopathy SS was the most frequent, significant differences were found in terms of fetal hemoglobin, which was higher in patients with negative microalbuminuria, with a 6,6 average. The urinary density showed an average of 1 014,6 for patients with negative microalbuminuria and 1 008,0 for those who had positive, significant differences were found. In patients with positive microalbuminuria the most frequent crisis was the acute chest syndrome (100%). Conclusions: the frequency of positive microalbuminuria behaved similar to some reviewed studies, an average age of 13 years was evident for these cases with count of higher reticulocytes, lower urinary density and higher frequency of abnormalities of the urinary sediment and acute chest syndrome of the rest of the group studied; most of them were undernourished.
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