medigraphic.com
ISSN 1995-9494 (Electronic)
Revista del Hospital Clínico Quirúrgico "Arnaldo Milián Castro"

2017, Number 1

<< Back Next >>

Acta Med Cent 2017; 11 (1)

Comportamiento de las alteraciones renales en pacientes pediátricos con drepanocitosis

García CMB, Arango ID, Cedré HT, García SD, López GC, Pérez PPN

Language: Spanish
References: 20
Page: 13-20
PDF size: 214.07 Kb.


ABSTRACT

Introduction: the drepanocytosis is a disease with multisystem impact. Renal disease begins in childhood and chronic consequences are glomerulopathy sickle glomerular with evolution to chronic renal failure. Objective: to know how renal disorders are expressed in pediatric patients with drepanocytosis. Method: a prospective descriptive study was realized in pediatric patients with drepanocytosis attended in the outpatient of Hematology at “José Luis Miranda” Hospital between August 2013 and December 2014. Sixteen asymptomatic patients were included in the last month without transfused in the previous three months. Clinical variables, hematological, biochemical and imaging were evaluated in order to describe the renal abnormalities. Results: three patients with positive microalbuminuria were diagnosed; the average age was 13 years, the hemoglobinopathy SS was the most frequent, significant differences were found in terms of fetal hemoglobin, which was higher in patients with negative microalbuminuria, with a 6,6 average. The urinary density showed an average of 1 014,6 for patients with negative microalbuminuria and 1 008,0 for those who had positive, significant differences were found. In patients with positive microalbuminuria the most frequent crisis was the acute chest syndrome (100%). Conclusions: the frequency of positive microalbuminuria behaved similar to some reviewed studies, an average age of 13 years was evident for these cases with count of higher reticulocytes, lower urinary density and higher frequency of abnormalities of the urinary sediment and acute chest syndrome of the rest of the group studied; most of them were undernourished.


REFERENCES

  1. Svarch E, Marcheco-Teruel B, Machín-García S, Menéndez-Veitía A, Nordet-Carrera I, Arencibia-Núñez A, et al. La drepanocitosis en Cuba. Estudio en niños. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2011 [citado 5 May 2015];27(1):51-67. Disponible en: http://scielo.sld.cu/pdf/hih/v27n1/hih05111.pdf

  2. Svarch E. Programa cubano de atención integral al paciente con drepanocitosis. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2011 [citado 14 Nov 2014];27(2):165-167. Disponible en: http://scielo.sld.cu/pdf/hih/v27n2/hih01211.pdf

  3. Riehm Meier E, Miller JL. Sickle cell disease in children. Drugs [Internet]. 2012 [citado 15 Jun 2014];72(7):895-906. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899685/

  4. López Revuelta K, Ricard Andrés MP. Afectación renal en la enfermedad falciforme. Nefrología (Madr.) [Internet]. 2011 [citado 19 Jun 2014]; 31(5):591-601. Disponible en: http://www.revistanefrologia.com/es-publicacion-nefrologia-articulo-afectacion-renal-enfermedad-falciforme-X0211699511052490

  5. Núñez-Quintana A, Hondal-Álvarez NI, Ayllón-Valdés L. Alteraciones renales en la drepanocitosis. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2011 [citado 22 May 2015];27(2):168-178. Disponible en: http://scielo.sld.cu/pdf/hih/v27n2/hih02211.pdf

  6. Aygun B, Mortier NA, Smeltzer MP, Hankins JS, Ware RE. Glomerular hyperfiltration and albuminuria in children with sickle cell anemia. Pediatr Nephrol [Internet]. 2011 [citado 27 Jun 2015];26:1285. Disponible en: http://health.springer.com/article/10.1007/s00467-011-1857-2/fulltext.html

  7. Becker AM. Sickle cell nephropathy: challenging the conventional wisdom. Pediatr Nephrol [Internet]. 2011 [citado 23 Jun 2015];26(12):2099-2109. Disponible en: http://health.springer.com/article/10.1007/s00467-010-1736-2/fulltext.html

  8. Ranque B, Menet A, Diop IB, Thiam MM, Diallo D, Diop S, et al. Early renal damage in patients with sickle cell disease in sub-Saharan Africa: a multinational, prospective, cross-sectional study. Lancet Hematol [Internet]. 2014 [citado 11 Jun 2015];1(2):e64-e73. Disponible en: http://www.thelancet.com/journals/lanhae/article/PIIS2352-3026%2814%2900007-6/fulltext

  9. Aloni MN, Ngiyulu RM, Gini-Ehungu JL, Nsibu NC, Ekila MB, Lepira FB, et al. Renal function in children suffering from sickle cell disease: challenge of early detection in highly resource- scarce settings. PloS One [Internet]. 2014 [citado 12 Jun 2015];9(5):e96561. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014510/

  10. Oña Aldama N, Díaz de Armas M, Rebull Pradas A, Russeaux Guía N. Estrategias para la introducción de nuevos diagnosticadores en el Sistema Nacional de Salud. Rev Cubana Farmac [Internet]. 2015 [citado 8 Ene 2016];49(2):197-208. Disponible en: http://scielo.sld.cu/pdf/far/v49n2/far02215.pdf

  11. Ministerio de Salud Pública. Umelisa microalbúmina. Para la cuantificación de albúmina humana en muestras de orina. La Habana: Centro de Inmunoensayo; 2009.

  12. King L, MooSang M, Miller M, Reid M. Prevalence and predictors of microalbuminuria in Jamaican children with sickle cell disease. Arch Dis Child [Internet]. 2011 [citado nov 2014];96(12):[aprox. 3 p.]. Disponible en: http://adc.bmj.com/content/early/2011/09/30/archdischild-2011-300628.abstract

  13. Asnani MR, Fraser RA, Reid ME. Higher rates of hemolysis are not associated with albuminuria in Jamaicans with sickle cell disease. PLoS One [Internet]. 2011 [citado junio 2015];6(4)e18863. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077410/pdf/pone.0018863.pdf

  14. Mawanda M, Ssenkusu JM, Odiit A, Kiguli S, Muyingo A, Ndugwa C. Micro-albuminuria in Ugandan children with sickel cell anaemia: a cross-sectional study. Ann Trop Paediatr [Internet]. 2011 [citado 8 Jun 2015]; 31. Disponible en: http://tandfonline.com/doi/abs/10.1179/1465328111Y.0000000013?journalCode=ypch19

  15. Osei-Yeboah CT, Rodrigues O. Renal status of children with sickle cell disease in Accra, Ghana. Ghana Med J [Internet]. 2011 [citado 8 Jun 2015];45(4):155-160. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283093/

  16. Bodas P, Huang A, O’Riordan MA, Sedor JR, Dell KM. The prevalence of hypertension and abnormal kidney function in children with sickle cell disease –a cross sectional review. BMC Nephrology [Internet]. 2013 [citado 11 Jun 2014];14(1):237. Disponible en: http://health.springer.com/article/10.1186/1471-2369-14-237/fulltext.html

  17. Kato GJ, Gladwin MT, Steinberg MH. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes. Blood Rev [Internet]. 2007 [citado 8 Jun 2014];21(1):37-47. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048670/

  18. Aygun B, Mortier NA, Smeltzer MP, Shulkin BL, Hankins JS, Ware RE. Hydroxyurea treatment decreases glomerular hyperfiltration in children with sickle cell anemia. Am J Hematol [Internet]. 2013 [citado 10 Jun 2015];88(2):116-119. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/ajh.23365/full

  19. Creary S, Zickmund S, Ross D, Krishnamurti L, Bogen DL. Hydroxyurea therapy for children with sickle cell disease: describing how caregivers make this decision. BMC Res Notes [Internet]. 2015 [citado 28 Sept 2015];8:372. Disponible en: http://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-015-1344-0

  20. 20.Shome DK, Al Ajmi A, Radhi AA, Mansoor EJ, Majed KS. The effect of hydroxyurea therapy in bahraini sickle cell disease patients. Indian J Hematol Blood Transfus [Internet]. 2016 [citado 28 Sept 2015];32:104. Disponible en: http://link.springer.com/article/10.1007%2Fs12288-015-0529-y#page-1




2020     |     www.medigraphic.com