2016, Number S2
PDF size: 288.90 Kb.
ABSTRACTBackground: Several studies have reported a correlation between vitamin D deficiency and insulin resistance; however, other clinical trials show that vitamin D supplementation do not normalize glucose and insulin levels. We designed a study to show if there is a correlation between serum vitamin D and the homeostatic model assessment 2 (HOMA 2).
Methods: it was designed a cross-sectional, descriptive, and analytical study, which included medical residents. They answered a questionnaire to record the time of sun exposure. We took anthropometric measurements, such as weight, height, and waist circumference, as well as some serum levels: serum vitamin D, serum insulin, fasting blood glucose, triglycerides and high-density lipoprotein-cholesterol. The correlation between serum vitamin D and HOMA 2 was determined by the correlation of Pearson; it was considered significant a p ‹ 0.05.
Results: The decreased serum vitamin D levels did not correlate with high concentrations of HOMA 2 (r = −0.11, p = 0.34). A negative correlation between vitamin D levels and index size waist was observed (r = −0.27, p = 0.025). HOMA 2 was positively correlated with waist size index (r = 0.23, p = 0.05) and triglycerides (r = 0.61, p = 0.01) and negatively with high density lipoprotein-cholesterol (r = −0.26, p = 0.02).
Conclusions: We couldn’t show the correlation between vitamin D deficiency and insulin resistance.
Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc. 2011;86:50-60.
Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med. 2002 Jun 1;112(8):659-62.
Pereira-Santos M, Costa PR, Assis AM, Santos CA, Santos DB. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev. 2015 Apr;16(4):341- 9. doi: 10.1111/obr.12239. Epub 2015 Feb 17.
Kunutsor SK, Apekey TA, Steur M. Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants. Eur J Epidemiol. 2013 Mar;28(3):205-21. doi: 10.1007/s10654-013-9790-2.
Mendoza V, Villanueva MT, Vargas G, González B, Halabe J, Simón J, et al. Vitamin D deficiency among medical residents and its relationship with metabolic indices. Endocr Pract. 2013 Jan-Feb;19(1):59-63. doi: 10.4158/EP12185.OR.
Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000 Sep;72(3):690-3.
Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81. DOI: 10.1056/NEJMra070553
Jorde R, Sneve M, Emaus N, Figenschau Y, Grimnes G. Cross-sectional and longitudinal relation between serum 25-hydroxyvitamin D and body mass index: the Tromsø study. Eur J Nutr. 2010 Oct;49(7):401-7. doi: 10.1007/s00394-010-0098-7.
Gradillas-García A, Álvarez J, Rubio JA, de Abajo FJ. [Relationship between vitamin D deficiency and metabolic syndrome in adult population of the Community of Madrid]. Endocrinol Nutr. 2015 Apr;62(4):180-7. doi: 10.1016/j.endonu.2014.12.008.
Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr. 2011 Sep;65(9):1005-15. doi: 10.1038/ejcn.2011.118.
Gallagher JC, Yalamanchili V, Smith LM. The effect of vitamin D supplementation on serum 25(OH) D in thin and obese women. J Steroid Biochem Mol Biol. 2013 Jul;136:195-200. doi: 10.1016/j. jsbmb.2012.12.003.
Carter GD, Carter R, Jones J, Berry J. How accurate are assays for 25-hydroxyvitamin D? Data from the international vitamin D external quality assessment scheme. Clin Chem. 2004 Nov;50(11):2195-7.
George PS, Pearson ER, Witham MD. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and metaanalysis. Diabet Med. 2012 Aug;29(8):e142-50. doi: 10.1111/j.1464-5491.2012.03672.x.
Pérez-Maraver M, Montanya-Mias E, Técnicas para el estudio de la resistencia insulínica. Una valoración crítica. AV Diabetol. 2001;17:179-86.
Geloneze B1, Vasques AC, Stabe CF, Pareja JC, Rosado LE, Queiroz EC, et al; BRAMS Investigators. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS). Arq Bras Endocrinol Metabol. 2009 Mar;53(2):281-7.
Eliades M, Pittas AG. Vitamin D and Type 2 Diabetes, Clinic Rev Bone Miner Metab. 2009;7;188-98.
Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care. 2007 Apr;30(4):980- 6. Epub 2007 Feb 2.
Lang PO, Samaras N, Samaras D, Aspinall R. How important is vitamin D in preventing infections. Osteoporos Int. 2013 May;24(5):1537-53. doi: 10.1007/ s00198-012-2204-6.
Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, Zimmet PZ, et al. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab. 2012 Jun;97(6):1953-61. doi: 10.1210/jc.2011-3187.
Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E15-26.
Haney, ME, Stadler D, Bliziotes MM. Vitamin D Insufficiency in Internal Medicine Residents. Calcif Tissue Int. 2005 Jan;76(1):11-6.
Ford ES, Ajani UA, Mcguire LC, Liu S. Concentrations of Serum Vitamin D and the Metabolic Syndrome Among U.S. Adults, Diabetes Care. 2005;28(5):1228-30.
Hurskainen AR, Virtanen JK, Tuamainen TP, Nurmi T, Vautilainen S. Association of serum 25-hydroxyvitamin D with type 2 diabetes and markers of insulin resistance in general older population in Finland. Diabetes Metab Res Rev. 2012;28(5):418-23.
Brenner DR, Arora P, Garcia-Bailo B, Wolever TM, Morrison H, EL-Sohemy A, et al. Plasma vitamin D levels and risk of metabolic syndrome in Canadians. Clin Invest Med. 2011;34(6):E377.
Kelishadi R, Salek S, Salek M, Hashemipour M, Movahedian M. Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: A triple-masked controlled trial. J Pediatr (Rio J). 2014;90:28-34.