2008, Number 1
Rev Neurol Neurocir Psiquiat 2008; 41 (1)
Polymiositis as a paraneoplasic syndrome: case report
Miranda NG, Carrasco VH, Díaz GLE
Full text
Language: Spanish
References: 3
Page: 37-39
PDF size: 160.03 Kb.
ABSTRACT
Introduction. As a paraneoplasic syndrome, the polymyositis is a disorder characterized by inflammation and necrosis of the muscle fibers, occasionally associated to skin affectation (dermatomyositis). The polymyositis can precede cancer by years, this is the reason these patients are considerate as risk population, mainly women. Approximately 9% of these patients will develop cancer. Malign process is detected in 15-20% of the patients with polymyositis diagnostic; the most frequent are brest cancer, lung cancer, ovary cancer, stomach cancer and no Hodgkin lymphoma. This disease goes with progressive proximal and symmetric muscle weakness with elevation of the muscular enzymes and a typical electromyographyc patron. The curse can be oscillated and the treatment is to attach the base tumor and the simultaneous administration of corticosteroids.Case report. Female patient 40 years old who is diagnose with left breast cancer has dealings with radical mastectomy and radiotherapy in march 2005; begins clinic symptoms on august of same year makes one debut with inferior extremities drowsiness, then superior extremities, with predominance was examinated by neurology service who determined the superior extremities weakness by exploration, taken muscular enzymes and then find high (CK 7800, LDH 2880) decided to make a muscle biopsy, reported compatibility with polymyositis.
Conclusions. The paraneoplasic syndromes are a group of symptoms does not caused by the tumor but of cancer’s products. Some tumour’s substances produced by the cancer are hormones, cytoquins and different proteins. These products have effects over the different organs and knits by chemical effects, with the result the paraneoplasic term. In the patient’s case presented in this article can adapt by the excellent approach and specific neurological exploration.
REFERENCES