2016, Number 4
Comparative study, using magnetic resonance, of the cingulate bundles and anterior thalamic radiations of patients with attention deficit disorder and healthy controls
PDF size: 493.20 Kb.
ABSTRACTIntroduction: attention deficit disorder is a common neurodevelopmental condition in childhood, predominant in males aged 7 years, but may persist into adulthood (2-5%). It is characterized by hyperactivity, lack of attention, and impulsiveness. Its prevalence varies from 3 to 7% worldwide, and in Mexico is 5%. It represents 44% of psychiatric consultations in public institutions, diagnosis is clinical, and its causes are multifactorial; magnetic resonance helps in studying such patients.
Objetive: determine, by tractography, differences in thickness of nerve bundles of the cingulum and anterior thalamic radiations between healthy persons and patients with attention deficit disorder.
Material and Method: a transverse, prospective, and comparative observational study in 5 patients with attention deficit disorder and 5 healthy subjects as controls. All were previously evaluated by pediatric psychiatry and then underwent tractography by magnetic resonance.
Results: we observed significantly greater thickness of tracts in the anterior thalamic radiation (p = 0.009) in the right hemisphere in patients with attention deficit disorder. Ninety percent of the patients evaluated were male and no differences in their laterality were observed.
Conclusions: increased thickness of tracts in the right anterior thalamic radiation is probably compensatory, in response to hypofunction of the cerebral cortex and thinning of the contralateral anterior thalamic radiation, given that neurochemical studies postulate alterations in regulation of catecholamines (dopamine and noradrenaline) in the prefrontal cortex, parietal lobe, cingulum, striate body, hippocampus, and thalamus.
Gustafsson P, Thernlund G, Ryding E, Rosén I, Cederblad M. Associations between cerebral blood-flow measured by single photon emission computed tomography (SPECT), electroencephalogram (EEG), behaviour symptoms, cognition and neurological soft signs in children with attentiondeficit hyperactivity disorder (ADHD). Acta Paediatrica 2000;89:830-5.
Philip Shaw, MD; Jason Lerch, PhD; Deanna Greenstein, PhD; Wendy Sharp, MSW; Liv Clasen, PhD; Alan Evans, PhD; Jay Giedd, MD; F. Xavier Castellanos, MD; Judith Rapoport, MD. Longitudinal Mapping of Cortical Thickness and Clinical Outcome in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder. Arch Gen Psychiatry. 2006;63:540-549.