Elnecavé LL, Bazán BA, González GA, Portilla FVH

Language: Spanish
References: 10
Page: 131-133
PDF size: 21.59 Kb.

ABSTRACT

Hypothesis. The presence of any alleles may be related with a duration of the renal graft of living donor larger than 5 years. Material and methods. The HLA of 59 patients that received renal graft from living donor since September 1991 to December 1998 were analyzed. The ages of the patients goes from 15 to 45 years old. Inclusion criterions: men and women of any age, that received a kidney from living donor during the period of time mentioned before. Exclusion criterions: patients that received renal graft from cadaverous donor. Results. Of the 59 patients included in the study, 36 had a renal graft survival larger than 5 years and 23 didn’t obtain that survival (61.01% of graft survival larger than 5 years). Class I alleles founded with more frequency in the 36 patients with graft survival larger than 5 years were A2 in 23 cases (63.8%), A28 in 15 cases (41.6%), and B35 in 13 cases (36.1%). Class II alleles founded with more frequency in the 36 patients with graft survival larger than 5 years were DR7 in 10 cases (27.7%), DQ7 in 9 cases (25%) and DR4 in 7 cases (19.7%). Class I alleles founded with more frequency in the 23 patients that didn’t obtain a graft survival larger than 5 years were A2 in 13 cases (56.5%), B35 in 11 cases (47.8%), and A28 in 10 cases (43.4%). Class II alleles more frequents in the 23 patients that didn’t obtain a graft survival larger than 5 years were DR7 in 8 cases (34.7%), and DQ7 in 4 cases (17.3%). Other alleles of class II didn’t represent more than 10% of frequency in this group of patients. Conclusions. According with the results, the frequencies of class I and class II alleles were very similar for both groups of patients, those who had a graft survival larger than 5 years, and those who didn’t obtain that survival. Therefore, we can infer that the presence of any alleles have no influence on the survival of renal graft from living donor.

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