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Ginecología y Obstetricia de México

Federación Mexicana de Ginecología y Obstetricia, A.C.
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2016, Number 05

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Ginecol Obstet Mex 2016; 84 (05)

Placental site trophoblastic tumor with atypical choriocarcinoma. Case Report

Álvarez-Goris MP, de la Torre y Fernández P, Huerta-Hentschel JM, Sánchez-Zamora R
Full text How to cite this article

Language: Spanish
References: 8
Page: 324-329
PDF size: 619.70 Kb.


Key words:

Placental site trophoblastic tumor, choriocarcinoma, pregnancy complications.

ABSTRACT

Background: The placental site trophoblastic tumor is the second rarest tumor of trophoblastic disease, with less than 300 cases reported. Clinical presentation it’s a diagnostic challenge, it has an unpredictable malignant potential, and it can develop choriocarcinoma and even have simultaneous presentation.
Case Report: We present the case of a 34 year old woman with chronic transvaginal bleeding since her last cesarean (five months ago), with histologic diagnosis of placental site trophoblastic tumor and inmunohistoquimic report of choriocarcinoma, this early diagnosis improves her survival prognostic.
Conclusion: placental site trophoblastic tumor and their evolution to choriocarcinoma have a low rate but it’s possible. That it’s the reason why complete diagnosis with biopsy, histologic and inmunohistoquimic report is mandatory to improve therapeutic.


REFERENCES

  1. Shih IeM. Gestational trophoblastic neoplasia-pathogenesis and potential therapeutic targets. Lancet Oncol 2007;8:642-650.

  2. Rauw L, Delbecque K, Goffin F, Golfier F, Georges P, Kridelka F. Atypical recurrence of a placental site trophoblastic tumor four years after hysterectomy for benign condition: Case report and review of literature. Gynecol Oncol Case Rep 2013;31(6):36-38.

  3. Altieri A, Franceschi S, Ferlay J, Smith J, La Vecchia C. Epidemiology and aetiology of gestational trophoblastic diseases. Lancet Oncol 2003;4:670-678.

  4. Lara FM, Alvarado AM, Candelaria M, Arce CS. [Gestational trophoblastic disease. Experience at National Institute of Cancerology].Enfermedad trofoblástica gestacional. Experiencia en el Instituto Nacional de Cancerología Ginecol Obstet Mex 2005;73(6):308-314.

  5. Hyman DM, Bakios L, Gualtiere G, Carr C, Grisham RN, Makker V, et al. Placental site trophoblastic tumor: Analysis of presentation, treatment, and outcome Gynecol Oncol 2013;129(1):58-62.

  6. Luiza JW, Taylor SE, Gao FF, Edwards RP. Placental site trophoblastic tumor: Immunohistochemistry algorithmkey to diagnosis and review of literature Gynecol Oncol Case Rep 2013;21(7):13-15.

  7. Huang F, Zheng W, Liang Q, Yin T. Diagnosis and treatment of placental site trophoblastic tumor. Int J Clin Exp Pathol 2013;6(7):1448-1451.

  8. Behtash N, Ghaemmaghami F, Hasanzadeh M. Long term remission of Metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature World J Surg Oncol 2005;15(1):34.




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Ginecol Obstet Mex. 2016;84