Arredondo-Ruiz P, González-Galván LM, Chac-Lezama G, Molina-Villena A, Sáenz-Castro M, Pérez-García JA, Alonso-Martínez D, Flores-Rivera O, Peña-Pérez CA, Bonilla-Castro C

Language: Spanish
References: 0
Page: 116-120
PDF size: 286.31 Kb.

ABSTRACT

Goodpasture’s disease is a clinical entity with an immunological pathophysiological basis, where the union to terminal NC1 domain mainly affects glomerular and lungs; thus, its diagnosis is oriented to such organ failure; its incidence varies from 0.5 to 1 cases per million population, for this reason it is considered a rare disease with high mortality due to complications from immune mechanism. Isolated lung presentation accounts for an even fewer percentage; in two thirds of cases hemoptysis is the most common clinical expression of the disease. Prognosis of these patients is associated to the presentation of the disease and the quality of care provided during the same. The definitive diagnosis is made by biopsy; however, the presence of anti-GBM antibodies (glomerular basement membrane) by ELISA can be handled in the diagnosis with good sensitivity.