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ISSN 2683-1678 (Print)
Órgano Oficial de la Sociedad
Latinoamericana de lnfectología Pediátrica.
Órgano de la Asociación Mexicana de
Infectología Pediátrica, A.C.
Órgano difusor de la Sociedad Española
de lnfectología

2017, Number 1

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Rev Latin Infect Pediatr 2017; 30 (1)

Recurrent respiratory papillomatosis in the pediatric population and a new strategy in the medical management adjuvant to surgery

Morales-Ayala LL, Hernández-Bautista VM, Gutiérrez-Hernández JA, Martínez-Ruiz CE, Xochíhua-Díaz L, Mayorga-Butrón JL

Language: Spanish
References: 29
Page: 22-27
PDF size: 254.92 Kb.


ABSTRACT

Recurrent respiratory papillomatosis is characterized with multiple benign proliferative lessions of the respiratory tract. It can cause airway obstruction that threatens life, quality of the voice and Health Related Quality of Life (HRQoL). Some reports have established 3,870 new cases per year in children in Mexico. The course of the disease is variable, some patients may experience spontaneous remission and others suffer aggressive disease with requirement of multiple surgeries for debulking procedures, which can lead to scarring, stenosis and loss of function. In order to reduce or eliminate the need for surgery, surgeons have used various adjuvant therapies, but so far there is no high-quality evidence to demonstrate adequate efficacy and safety profile of those therapies. Transfer factor has an immunomodulatory effect, which in certain circumstances in vitro, has demonstrated to modify immune response. Five cases of patients with recurrent respiratory papillomatosis treated with transfer factor in our institution are presented.


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