medigraphic.com
Anales de la Sociedad Mexicana de Oftalmología y Archivos de la Asociación Para Evitar la Ceguera en México

2005, Number 4

<< Back Next >>

Rev Mex Oftalmol 2005; 79 (4)

Comparative clinical study of the efficacy of three concentrations of topic ophthalmic phnylephrine in pediatric population.

Baiza-Durán LM, González JR, Tornero-Montaño R

Language: Spanish
References: 9
Page: 211-214
PDF size: 235.51 Kb.


ABSTRACT

Purpose: To compare the mediate efficacy of three different concentrations of phenylephrine, applied in healthy children.
Material and methods: A prospective, descriptive, double blind and longitudinal study was made. We included 30 eyes from 30 patients, between 1 and 12 years old, in which a routine ophthalmoscopy was performed. In each one, in a randomized way, one of the three formulations concentrations of topic phenylephrine eye drops were applied (2.5%-10 patients, 5%-10 patients and 10%-10 patients). Horizontal and vertical pupil diameter measures were made at different time intervals.
Results: The patients who received 10% topic phenylephrine showed bigger vertical as well as horizontal pupil diameters than those with the other concentrations when were compared.
Conclusions: 10% ophthalmic phenylephrine shown to be more effective than 2.5% and 5% phenyleprine eye drops to induce mydriasis in children.


REFERENCES

  1. 1. Hakim OJ, Orton RB, Cadera W. Topical 2.5% and 5% phenilephrine: comparison of effects on heart rate and blood pressure. Can J Ophthalmol. 1990; 25(7):337-339

  2. 2. Mydriatics and cycloplegics. En: Ophthalmic Drug Facts 1993. Wolters Kluwe Co. (ed). pp 41-45

  3. 3. Mydriatics and cycloplegics. En: Physicians Desk reference. 29 ed. 2001.

  4. 4. Mydriatics and cycloplegics. En: Ocular Therapeutics and Pharmacology. Philip P. Ellis (ed). Mosby, 1981. pp 274-275.

  5. 5. Merrit JC, Kraybill EN. Effect of mydriatics on blood pressure in premature infants. J Ped Ophthal and Strab 1981; 18(5):42-46.

  6. 6. Patton TF, Robinson JR. Pediatric dosing considerations in ophthalmology. J Ped Ophthal 1976; 13:171-178.

  7. 7. Fraunfelder FT, Scafidi AF. Possible adverse effects form topical ocular 10% phenylephrine. Am J Ophthal 1978; 85:447-453.

  8. 8. France TD, France NK. Mydriatic agents in premature infants (letter). Am J Ophthal 1973, 76(5):857.

  9. 9. Smith RB, Read S, Oczypok PM. Mydriatic effect of phenylephrine. Eye Ear Nose Thr Mon 1976; 55:133-134.




2020     |     www.medigraphic.com