2017, Number 2
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Rev Clin Esc Med 2017; 7 (2)
Acromegalia
Herra LG, Rojas NK, Alfaro RM
Language: Spanish
References: 24
Page: 11-19
PDF size: 319.18 Kb.
ABSTRACT
Acromegaly is a disease caused by the excessive
production of growth hormone, commonly by a
pituitary adenoma. There are two histologic subtypes,
densely granulated or sparsely granulated.
The clinical manifestations include visceromegaly,
changes in soft tissue, excessive
sweating, tumor mass effects, cardiovascular,
metabolic and respiratory disorders, manifestations
in bones and joints or endocrine repercus-
sions. To make the diagnosis, it is important to
measure insulin-like growth factor-1 levels and
an oral glucose tolerance test to determine
growth hormone levels. The different modalities
of treatment include surgery, medical therapy or
radiotherapy. Surgery is the first line treatment
for most of the patients with acromegaly, although
the decision is based in multiple factors,
the treatment should be individualized and the
patient should be evaluated by a multidisciplinary
team. Some cases may need combination
therapy to achieve the treatment goals.
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