medigraphic.com
SPANISH

Revista Cubana de Medicina Militar

ISSN 1561-3046 (Electronic)
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2016, Number 2

<< Back Next >>

Rev Cub Med Mil 2016; 45 (2)

Clinical characterization of cirrhotic patients with hypertensive portal gastropathy

Pérez LM, Infante VM, Ávalos RM, Guerrero GY, Román MY, Rodríguez ÁD
Full text How to cite this article

Language: Spanish
References: 30
Page: 172-182
PDF size: 112.21 Kb.


Key words:

hepatic cirrhosis, hypertensive portal gastropathy, gastrointestinal bleeding, portal hypertension.

ABSTRACT

Introduction: Hypertensive portal gastropathy (HPG) is a complication of portal hypertension of clinical relevance, which appears in patients with liver cirrhosis. Objective: Characterize the different types of hypertensive portal gastropathy (HPG) according to the presence of manifestations of portal hypertension, the state of liver function and the occurrence of digestive bleeding events. Method: A descriptive, cross-sectional study was conducted in 46 patients diagnosed with cirrhosis and endoscopic evidence of portal hypertensive gastropathy (HPG), treated from 2011 to 2013 in the Gastroenterology Department of Dr. Luis Díaz Soto Central Military Hospital. They were classified according to mild or severe form and comparisons were made between both groups. Results: 78.2% of the patients presented mild gastropathy and the most frequent location was the gastric fundus (78.2%). All cases with the severe form were men (p = 0.008). Among those who had severe gastropathy, those with larger diameter of the portal (18.3 mm vs 13.5 mm, p = 0.001) and spleen (137.4 mm vs 130.03 mm, p = 0, 0002), as well as those who also had esophageal varices (100%, p = 0.007), so that acute bleeding was also more frequent among them (60%, p = 0.01). Hematologic factors of portal hypertension or with degrees of liver function, although 63% of patients were found in groups B and C of the Child-Pughs-Turcotte classification. Conclusions: The severe form of hypertensive portal gastropathy (GPH) is the least frequent, but it is accompanied by relevant clinical, humoral and imaging alterations, which require a personalized attention for this type of patients.


REFERENCES

  1. McCormack TT, Sims J, Eyre-Brook I, Kennedy H, Goepel J, Johnson AG, et al. Gastric lesions in portal hypertension: inflammatory gastritis or congestive gastropathy? Gut. 1985;26(11):1226-32.

  2. Pique JM. Portal Hypertensive gastropathy. Baillieres Clin Gastroenterol. 1997;11(2):257-70.

  3. Cubillas R, Rockey DC. Portal hypertensive gastropathy: a review. Liver Int [Internet]. 2010 Sep [cited 2015 Nov 16]; 30(8):1094-102. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2010.02286.x/full

  4. Perini RF, Camara PR, Ferraz JG. Pathogenesis of portal hypertensive gastropathy: translating basic research into clinical practice. Nat Clin Pract Gastroenterol & Hepatol [Internet]. 2009 Mar [cited 2015 Mar 11]; 6(3):150-8. Available from: http://www.nature.com/nrgastro/journal/v6/n3/full/ncpgasthep1356.html

  5. Patwardhan VR, Cardenas A. Review article: the management of portal hypertensive gastropathy and gastric antral vascular ectasia in cirrhosis. Alimentary Pharmacol Ther [Internet]. 2014 Aug [cited 2016 Jan 13]; 40(4):354-62. Available from: http://onlinelibrary.wiley.com/doi/10.1111/apt.12824/full

  6. Samada Suarez M, Hernandez Perera JC, Ramos Robaina L, Barroso Marquez L, Gonzalez Rapado L, Cepero Valdes M, et al. Factors that predict survival in patients with cirrhosis considered for liver transplantation. Transplant Proc [Internet]. 2008 Nov [cited 2013 Nov 23]; 40(9):2965-7. Available from: https:// www.clinicalkey.com/#!/content/playContent/1-s2.0-S0041134508011883

  7. de Franchis R. Updating consensus in portal hypertension: report of the Baveno III Consensus Workshop on definitions, methodology and therapeutic strategies in portal hypertension. Journal Hepatol [Internet]. 2000 [cited 2015 Jul 29]; 33(5):846-52. Available from: http://www.journal-of-hepatology.eu/article/S0168- 8278(00)80320-7/fulltext

  8. de Franchis R, Pascal J, Ancona E. Definitions, methodology and therapeutic strategies in portal hypertension. A Consensus Development Workshop, Baveno, Lake Maggiore, Italy, April 5 and 6, 1990. J Hepatol. 1992;15:256-61.

  9. Sarin S, Kumar A. Gastric varices: profile, classification, and management. Am J Gastroenterol. 1989;84:1244-9.

  10. Child C, Turcotte J. Surgery and portal hypertension. In: Child CG, editor. The liver and portal hypertension. Philadelphia: W B Saunders Co; 1964. pp. 50-64.

  11. Piñero R, Olavarria R, Urquiola G, Yaraure M, Ramon Poleo J. Gastropatia portal hipertensiva: correlacion endoscópico histológica. GEN. 1994;48(1):7-9.

  12. Fontana RJ, Sanyal AJ, Ghany MG, Bonkovsky HL, Morgan TR, Litman HJ, et al. Development and progression of portal hypertensive gastropathy in patients with chronic hepatitis C. Am J Gastroenterol [Internet]. 2011 [cited 2015 May 29]; 106(5):884-93. Available from: http://www.nature.com/ajg/journal/v106/n5/full/ajg2010456a.html

  13. Licks F, Marques C, Zetler C, Martins MI, Marroni CA, Marroni NP. Antioxidant effect of N-acetylcysteine on prehepatic portal hypertensive gastropathy in rats. Ann Hepatol [Internet]. 2014 May-Jun [cited 2016 Jan 06]; 13(3):370-7. Available from: http://www.annalsofhepatology.com/revista/numeros/2014/10_143_v13n3_2014_ AntioxidantEffect.pdf

  14. Cuba. Ministerio de Salud Pública. Dirección Nacional de Estadísticas. Anuario Estadístico de Salud 2015 [Internet]. La Habana: MINSAP; 2016 [citado 19 jul 2016]. Disponible en: http://files.sld.cu/dne/files/2016/04/Anuario_2015_electronico-1.pdf

  15. Abbasi A, Bhutto AR, Butt N, Munir SM, Dhillo AK. Frequency of portal hypertensive gastropathy and its relationship with biochemical, haematological and endoscopic features in cirrhosis. J Coll Physicians Surg Pak [Internet]. 2011 Dec [cited 2015 Nov 26]; 21(12):723-6.]Available from: http://www.jcpsp.pk/archive/2011/Dec2011/02.pdf

  16. Kim MY, Choi H, Baik SK, Yea CJ, Won CS, Byun JW, et al. Portal hypertensive gastropathy: correlation with portal hypertension and prognosis in cirrhosis. Dig Dis Sci.[Internet]. 2010 Dec [cited 2015 Jul 15]; 55(12):3561-7. Available from: http://link.springer.com/article/10.1007/s10620-010-1221-6/fulltext.html

  17. Cerpa Polar R, Castro Valdivia R, Valdez Herrera J. Gastropatía Portal Hipertensiva en el Hospital Nacional del Sur - IPSS Arequipa. Rev Gastroenterol Peru. 1998;18(2):121-231.

  18. Sarin SK, Sreenivas DV, Lahoti D, Saraya A. Factors influencing development of portal hypertensive gastropathy in patients with portal hypertension. Gastroenterology. 1992;102(3):994-9.

  19. Merli M, Nicolini G, Angeloni S, Gentili F, Attili AF, Riggio O. The natural history of portal hypertensive gastropathy in patients with liver cirrhosis and mild portal hypertension. Am J Gastroenterol. 2004;99(10):1959-65.

  20. Kumar A, Mishra SR, Sharma P, Sharma BC, Sarin SK. Clinical, laboratory, and hemodynamic parameters in portal hypertensive gastropathy: a study of 254 cirrhotics. J Clin Gastroenterol. 2010;44(4):294-300.

  21. Primignani M, Carpinelli L, Preatoni P, Battaglia G, Carta A, Prada A, et al. Natural history of portal hypertensive gastropathy in patients with liver cirrhosis. The New Italian Endoscopic Club for the study and treatment of esophageal varices (NIEC). Gastroenterology. 2000;119(1):181-7.

  22. Zardi EM, Uwechie V, Gentilucci UV, Dobrina A, Petitti T, Laghi V, Picardi A, Afeltra A. Portal diameter in the diagnosis of esophageal varices in 266 cirrhotic patients: which role? Ultrasound Med Biol. 2007;33:506-11.

  23. Ohta M, Yamaguchi S, Gotoh N, Tomikawa M. Pathogenesis of portal hypertensive gastropathy: a clinical and experimental review. Surgery. 2002;131(1 Suppl):S165-70.

  24. Kumar A, Mishra SR, Sharma P, Sharma BC, Sarin SK. Clinical, laboratory, and hemodynamic parameters in portal hypertensive gastropathy: a study of 254 cirrhotics. J Clin Gastroenterol. 2010;44(4):294-300.

  25. Samada M, Hernández J, Barroso L, Chao L, González M, Fernández I. Identificación de factores de riesgo de presencia de várices esofágicas en pacientes con cirrosis hepática. Rev Cub Med Mil [Internet]. 2008 [citado 06 jun 2015]; 37(1) Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138- 65572008000100002&lng=es

  26. Infante Velázquez M, Fuentes Ramos M, Pérez Lorenzo M, Ramos Contreras Y, Winograd Lay R, Angulo Pérez O. Ligadura endoscópica de várices esofágicas más propranolol para profilaxis secundaria del sangrado digestivo en pacientes cirróticos. Rev Cubana Med Mil [Internet]. 2013 [citado12 jul 2014]; 42:39-48. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138- 65572013000100006&nrm=iso

  27. Urrunaga NH, Rockey DC. Portal hypertensive gastropathy and colopathy. Clin Liver Dis [Internet]. 2014 May [cited 2015 Dec 03]; 18(2):389-406. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528620/

  28. Qureshi K, Al-Osaimi AM. Approach to the management of portal hypertensive gastropathy and gastric antral vascular ectasia. Gastroenterol Clin NA [Internet]. 2014 Dec [cited 2015 Nov 23]; 43(4):835-47. Available from: http://www.sciencedirect.com/science/article/pii/S0889855314001022

  29. Zardi EM, Ghittoni G, Margiotta D, Viera FT, Di Matteo F, Rossi S. Portal hypertensive gastropathy in cirrhotics without varices: a case-control study. Eur J Gastroenterol Hepatol. 2015;27(1):91-6.

  30. Lahbabi M, Mellouki I, Aqodad N, Elabkari M, Elyousfi M, SA I, et al. Esophageal variceal ligation in the secondary prevention of variceal bleeding: Result of long term follow-up. Pan Afr Med J [Internet]. 2013 May [cited 2015 Feb 17];15:3-7. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708329




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Rev Cub Med Mil . 2016;45