Belfort PLF, Tadeu VR, Fortes BBVAC

Language: Portugu?s
References: 10
Page: 52-54
PDF size: 373.15 Kb.

ABSTRACT

Psoriasis is a chronic inflammatory disease characterized by epidermal hyperplasia mediated by T lymphocytes. It is known that one of the key cytokines involved in the pathogenesis of the disease is tumor necrosis factor (TNF-α) and several treatments currently proposed have in common the phenomenon of tachyphylaxis. Being pentoxifylline able to antagonize the production and activity of TNF alpha, two cases of psoriasis refractory to conventional treatments are described, in which pentoxifylline was introduced and there was a significative reduction in PASI.

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