medigraphic.com
SPANISH

Revista Mexicana de Urología

Organo Oficial de la Sociedad Mexicana de Urología
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Authors instructions        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2017, Number 5

Rev Mex Urol 2017; 77 (5)

Renal unicentric Castleman’s disease

Gómez-Sánchez J, Herrera-Muñoz J, Preciado-Estrella DA, Trujillo-Ortiz L, Sedano-Basilio J, Viana-Álvarez G
Full text How to cite this article

Language: Spanish
References: 9
Page: 389-392
PDF size: 284.09 Kb.


Key words:

Castleman’s disease, Lymphoproliferative disorders, Kidney cancer.

ABSTRACT

Background: Castleman’s disease describes a group of lymphoproliferative disorders caused by excessive proinflammatory cytokine production, mainly of interleukin-6. Patients present with heterogeneous clinical features, with histopathologic lymph node changes, and often with multiple organ failure.
Clinical case: A 70-year-old man had a past medical history of type 2 diabetes mellitus and high blood pressure. A left Bosniak I renal cyst and a 36-mm mass occupying the ipsilateral pelvic region were incidentally diagnosed. Kidney scintigram revealed a glomerular filtration rate of 22.5 mL/min in the right kidney and of 39.3 mL/min in the left kidney. Complementary urinary cytology study was negative. Laboratory test results were: hemoglobin 14.6 mg/dL, hematocrit 38%, leukocytes 7240, platelets 226000, PT 15.2, PTT 32 sec, glucose 158 mg/dL, creatinine 0.7, and nonpathologic urinalysis. Radical nephrectomy was performed with no early or intermediate complications, metabolic control and hemodynamic control were adequate, and the patient was released. The histopathologic result was lymphoplasmacytic tumor in the adipose tissue of the renal hilum (3.5 cm) consistent with Castleman’s disease.
Conclusions: Castleman’s disease is difficult to diagnose. Histopathologic study is essential, and given the low frequency of the disease, ideal management has not been established. However, surgical excision is the only curative option in its unicentric variants.


REFERENCES

  1. Castleman B, Towne V. Case records of the Massachusetts General Hospital: Case no 40231. N Engl J Med 1994;250:1001-1005.

  2. Bowne J, Lewin JJ, Filippa DA, et al. The management of unicentric and multicentric Castleman’s disease. A report of 16 cases and a review of the literature. Cancer 1999;85:706-717.

  3. Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 2002;29:670-683.

  4. Frizzera G, Peterson BA, Bayrd ED, et al. A systemic lympho- proliferative disorder with morphologic features of Castleman’s disease: clinical findings and clinicopathologic correlations in 15 patients. J Clin Oncol 1985;3:1202-1216.

  5. Roca B. Castleman’s disease. A Review. AIDS Rev 2009;11:3- 7.

  6. Casper C. New approaches for the treatment of human herpes virus 8-associated disease. Rev Med Virol 2008;18:321-329.

  7. Candelaria M, Luna-Ochoa E, Labardini-Mendez J, et al. Virus y neoplasias hematológicas. Rev del Instituto Nacional de Cancerología 2009;4:217-235.

  8. Dham A, Peterson B. Castleman disease. Curr Opin Hematol 2007;14:354-359.

  9. Cronine D, Warneke WA. Castleman ́s disease. An update on classification and the spectrum of associated lesions. Adv Anat Pathol 2009;16:236-246.




2020     |     www.medigraphic.com

Mi perfil

CÓMO CITAR (Vancouver)

Rev Mex Urol. 2017;77