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2005, Number 1

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Rev Hosp Jua Mex 2005; 72 (1)

Radiosulforhodamine 101 (SRF 101) for diagnoses and treatment of the astrocyhtomes

Vargas SJ, Skromne KG, Hidalgo RR
Full text How to cite this article

Language: Spanish
References: 4
Page: 16-17
PDF size: 48.30 Kb.


Key words:

Sulforhodamine 101, radiolabel, astrocytomes.

ABSTRACT

We labell sulforhodamine 101 (SR 101) with radionuclides betta and gamma emisors for the diagnosis and treatment of astrocytomes craneal tumors. We make the clasical test of radiocrhomathography, radiopharmaceutical and genetical probes in experimental animals with good results, so we can take scans of astrocytomes and other craneal tumors in 14 cases and only the astrocytomas take the SR 101 and give “positive” centelleographies (fig. 1) (4 cases). Also in 2 selected cases of astrocytoma (non quirurgical) we give terapehutical doses of SR 101 gamma emisor with good results in one year of follow-up and in a harmless form. because of the encorageous results and the non adverse reaccions we propoused the SR 101 radiopharmaco for the early diagnoses and treament of the astrocyhtomes.


REFERENCES

  1. Nimmerjahn A, Kirchoff F, Kerr J, Helmchen F. Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo nature methods. Oct. 2004; Vol 1(1): 31.

  2. Bigner DD, Mc.Lendon RE, Bruner JM, (ed) in Rusell R. Rubinstein’s pathology of the tumors of the nervous system. New York Univ Press 1998.

  3. Álvarez-Cervecera J, Skromne-Kadlubik G. On the preparation of radiactive DDD. Journal Inter Applied Isotopes 1993. Vol 24(187).

  4. Ng HK, Lamp P. The molecular genetics of central nervous system tumors. Patology 1998; 30: 196.




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C?MO CITAR (Vancouver)

Rev Hosp Jua Mex. 2005;72