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Federación Mexicana de Ginecología y Obstetricia, A.C.

2017, Number 10

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Ginecol Obstet Mex 2017; 85 (10)

Pregnancy rates in the first cycle of intrauterine insemination with gonadotropin stimulation in relation to number of follicles and age

Amézquita-Vizcarra LE, Barros-Delgadillo JC, Muñoz-Manrique CG

Language: Spanish
References: 12
Page: 659-667
PDF size: 456.06 Kb.


ABSTRACT

Objetive: To determine the clinical pregnancy rate in the first cycle of intrauterine insemination with gonadotropin stimulation in relation to number of mature follicles and age and the use of GnRH antagonist on its development.
Materials and Methods:: Analytic, retrospective study, we evaluated the first IUI cycle in 171 women stimulated with different protocols of ovarian stimulation in a period of two years. The patients were divided into two groups: ‹35 and ≥35 years old and the use of GnRH antagonist.
Results: 60.4 and 65.1% of patients ‹35 and ≥35 years old respectively, developed 2 to 4 mature follicles; the clinical pregnancy rate ‹35 and ≥35 years old was 27.7 y 28.5% and 54.5 and 57.4% with 1 and 4 mature follicles developed, we found a proportional relation between mature follicles and pregnancy rates. The ongoing pregnancy rates was 19.8 y 13.3% in ‹35 y ≥35 years respectively. The use of antGnRH does not appear to be related to better pregnancy rates in cycles with more than one mature follicle.
Conclusions: we found a proportional relation between mature follicles and pregnancy rates. The use of antGnRH does not appear to be related to better pregnancy rates in cycles with more than one mature follicle. The target in ovarian stimulation and IUI must be the development of 2 or 3 matures follicles.


REFERENCES

  1. Merviel P, Heraud MH, Grenier N, Lourdel E, Sanguinet P, Copin H. Predictive factors for pregnancy after intrauterine insemination (IUI): An analysis of 1038 cycles and a review of the literature. Fertil Steril 2010;93(1):79-88.

  2. Monraisin O, Chansel-Debordeaux L, Chiron A, Floret S, Cens S, Bourrinet S, et al. Evaluation of intrauterine insemination practices: a 1-year prospective study in seven French assisted reproduction technology centers. Fertil Steril 2016;105(6):1589-93.

  3. Dinelli L, Courbiere B, Achard V, Jouve E, Deveze C, Gnisci A, et al. Prognosis factors of pregnancy after intrauterine insemination with the husband’s sperm: conclusions of an analysis of 2,019 cycles. Fertil Steril 2014;101(4):994-1000.

  4. Babita P, Lita M, Mahesh C S, Rabindra NP. Success in Pregnancy Through Intrauterine Insemination at First Cycle in 300 Infertile Couples. An Analys J Obstet Gynaecol India 2014;64(2):134-42.

  5. Barros-Delgadillo JC, Trejo-Castañeda H, Ormsby C, Gaviño- Gaviño F. Diferencia de respuesta a los antagonistas de GnRH en ciclos de hiperestimulación ovárica más inseminación intrauterina. Ginecol Obstet Mex 2010;78(1):15-28.

  6. Barros Delgadillo JC, Rojas Ruiz JC, Molina Munguía AC, Villalobos Acosta S, Sánchez Solís V, Barroso Villa G, Gaviño Gaviño F. Factores pronóstico de embarazo en inseminación intrauterina. Ginecol Obstet Mex 2006;74:611-25

  7. Kamath MS, Bhave P, Aleyamma TK, Mangalaraj AM, Muthukumar K, George K. Predictive factors for pregnancy after intrauterine insemination: A prospective study of factors affecting outcome. J Hum Reprod Sci. 2010; 3(3):129-34.

  8. Ghesquiere SL, Castelain EG, Spiessens C, Meuleman CL, D’Hooghe TM. Relationship between follicle number and (multiple) live birth rate after controlled ovarian hyperstimulation and intrauterine insemination. Am J Obstet Gynecol 2007;197:589.e1-589.e5.

  9. Rumste V, Custers IM, Vander Veen F, Wely V, Evers JL, Mol BW. The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation: a meta-analysis. Human Reprod Update 2008;14(6):563-70.

  10. The ESHRE Capri Workshop Group, Intrauterine insemination. Human Reproduction Update, 2009;15(3):265-77.

  11. Gomez-Palomares JL, Acevedo-Martın B, Chavez M, Manzanarez M, Ricciarelli E, Hernández ER. Multifollicular recruitment in combination with gonadotropinreleasing hormone antagonist increased pregnancy rates in intrauterine insemination cycles. Fertil and Sterility, 2008;89(3):624-4

  12. Luo S, Li S, Jin S, Li Y, Zhang Y. Effectiveness of GnRH antagonist in the management of subfertile couples undergoing controlled ovarian stimulation and intrauterine insemination: a meta-analysis. PLoS One. 2014; 9: e109133




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