Guzmán-López R, García-Cruz D, Magallanes-Ordoñez JJ, Siliceo-Murrietad J, Dávalos-Rodríguez NO, Ruiz-Mejía R, Madrigal-Ruiz PM, Cruz-Bastida JM, Cruz-Bastida JS, Duque-Bautista H, Ramón-Canul L, Castro-Juárez CJ, Ramírez-García SA

Language: Spanish
References: 12
Page: 134-139
PDF size: 562.11 Kb.

ABSTRACT

Introduction. The ATXN2 gene codes for the protein ataxin-2, which is a protein involved in the neuritogenesis In murine models, its deficiency in embryonic hypothalamic cells is associated with the development of obesity, fatty liver and decreased expression of the insulin receptor. In mexican population there has not been a study analizating this association so the objective of the present study was to analyze the existence of a relationship between the distribution of alleles of the VNTR (variable number of tandem repeats) (CAG) n in exon 1 of ATXN2 and obesity in pediatric patients with insulin resistance.
Material and Methods. From March 2010 to August 2014 through the clinic for chronic degenerative diseases of the Research Unit in Epidemiology of the Municipal System for the Integral Development of the Family (DIF) in Chapala, Jalisco, and the Mexican Foundation for Genetic Diseases and Genomic Medicine AC analyzed 785 native children and residents of the riverside of Chapala, with indigenous ancestry in the region of five generations ago. Those with index were selected HOMA mayor 2. Two groups are formed, one consisting of 29 children with obesity grade II and the other group formed by 56 probands without obesity and without overweight. The polymorphism of ATXN2 by PCR end-point and the association with the diagnosis of obesity was analyzed.
Results. No association was found between ATXN2 VNTR and childhood obesity in our population. The Genotypic and allelic frequencies are similar to those reported in other populations. It was found as polymorphic the allele of 11 repetitions.
Discussion. In this study, the ATXN2 VNTR showed no influence on the development of childhood obesity in inhabitants and residents of the Ribera de Chapala, Jalisco.

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