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Boletín Clínico de la Asociación Médica del Hospital Infantil del Estado de Sonora

2017, Number 2

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Bol Clin Hosp Infant Edo Son 2017; 34 (2)

Ventana de esteroide en niños con Leucemia Linfoblástica Aguda evaluada por factores pronósticos

Rendón-García H, Tamayo PG, Covarrubias-Espinoza G

Language: Spanish
References: 13
Page: 82-89
PDF size: 389.13 Kb.


ABSTRACT

The steroid window is a part of the initial therapy for Acute Lymphoblastic Leukemia (ALL) and it is used to evaluate the medical response as a prognostic factor. The purpose is to identify the association of steroid response as a relapse predictor. Transversal study in ALL patients, non probabilistic by convenience sampling, there were prognosis factors for ALL including clinical risk, steroid response evaluated as good/bad responder. Descriptive analysis, the associations were examined by a logistic regression model and Kaplan Meyer. 70 patients were studied, with a high group risk in a 59%, B-cell Leukemia was presented in 92%, T-cell Leukemya in 6%, abnormal karyotype was registered in 30%. The response to the steroid window, ‹1000 blasts in peripheral blood at 8th day of treatment, demonstrated 11% of bad responders, 89% had a good response. Leucocytes ›50000 mm3 registered an OR at 95% of 5 (CI 0.06-0.72); the OR for abnormal karyotype at 95% was 3.7 (CI 1.04-12.82). The disease-free survival reported 55% for patients with good response to steroids and 15% in bad responders. The steroid window is an important factor that evaluates the early response to the treatment.


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