Vergara LA, Guillén GMA, Quintero CBP, Valdéz SH, Romero VG

Language: Spanish
References: 10
Page: 26-29
PDF size: 52.41 Kb.

ABSTRACT

A 64-year-old, non-obese, with no previous immune-disease female patient was diagnosed to diabetes mellitus secondary to antiinsulin receptor antibodies. Her illness begun 8 years ago with diabetes mellitus was diagnosed by high blood glucose concentration higher than 11 mM/L and classical symptoms. She was treated with sulfonilurea. One year later, due to lack of control, it is catalogued as primary failure to sulfonilurea. After this result, she was treated with a mixture of Metformin and Glyburide for one year without improvement. One year later, she is catalogued as insulin requiring patient and treated with small doses, due to frequent hypoglycemia. Ten months later, due to irregular control, rapid-action insulin and NPH insulin were used without positive results. During this time, the patient had four hospital incomes due to severe hypoglycemia. Afterwards she is income to hospital to demonstrate that her illness is brittle diabetes, and is confirmed. However, two months later she is income again due to marked oscillations in the glucose. This time, insulin and c-peptide were analyzed, being both antibodies high. Due to this result, antiinsulin and antibodies insulin receptor, were analyzed, both were positive. It is treated with Azathioprine for 6 months, without positive results; subsequently it is treated with Ciclophosphamide without benefit pulses.

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