Valerdi-F ML, Resendiz-C J, Labastida-A S, Gallegos-H F, Kimura-F T

Language: Spanish
References: 8
Page: 1526-1529
PDF size: 175.96 Kb.

ABSTRACT

Introduction. The malignant melanoma occurring in the mucous membrane is rare a has, until lately, remained unrecognized. The incidence of MPMB has ranged from 2 a 8% of all melanomas. An analysis has been made the retrospective study. Departments of Surgical Oncology and Surgery Maxillofacial of National Medical Center S. XXI IMSS; Ciudad de México. Objective. Malignant primary melanoma in mucous membrane of oral cavity is relatively infrequent, therefore analysis of its different modalities becomes quite complex, advances in diagnostically techniques and treatment have obvious influence in survival of skin melanoma’s patients, but the impact of MPMB remains undefined, intent in finding the impact of treatment in a group of patients (Mexican) suffering MPMB, de most recurrent common place were analyzed as well as a disease free period and survival rate. Results. Patients eight, four males, four females, age, 40-85 (median 61), pigmented lesions in oral cavity. All of them pain 25%. Bleeding 38%. Lesions: hard palate 75%, upper gum 12.5% soft palate 12.5%. Damage size: 5 cm (2-7 cm). Classification: clinical step I, five patients (62.5%), step II, three patients (37.5%), step III, none. Surgery: within all surgical limits. six patients, three with bone infiltration, underwent radio-therapy (RT), neck ganglionic dissection on two patients. Not susceptible to dry. Two patients treated with RT and palliative chemotherapy. Local recurrence: 50% regional, 62% distant. Patients that underwent surgery present recurrence after a disease free period of only seven months. Only one patient could be intervened with rescue surgery. Survival: Specific range of up to five years is 37.5% patients considered candidates to palliative therapy died within an average interval of 16 months. Conclusions. MPMB is a severe disease, generally not foreseeable, with hard to alter natural history, although the majority of patients initially seen as with a localized disease, there exists a high percentage of local recurrence, probably a result of tumoral infiltration. In this group, 62% presented neck ganglionic invasion, this being a higher percentage than previously reported in past occasions. The infiltration level and clinical steps are the most important prognostical factors. Every patient with deep infiltration and metastatic ganglia presented local recurrence.

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