medigraphic.com

2018, Number 3

<< Back Next >>

Rev Med MD 2018; 9.10 (3)

Zoledronic acid for idiopathic juvenile osteoporosis

Delgadillo-Alcaraz V, Cuevas-De Alba C, Flores-Navarro HH, Arana- Hernández EI

Language: Spanish
References: 12
Page: 245-249
PDF size: 714.68 Kb.


ABSTRACT

OJI is a rare bone metabolic disease of unknown etiology and clinical symptoms that affects prepubertal. It is characterized by fractures of the vertebral bodies and long bones, with generalized osteopenia. We present a case of OJI in a nine-year-old child male, referring to the clinical and imaging manifestations before and after the use of zoledronic acid, calcitriol and vitamin D. The reason for initial consultation was back pain and inability to walk. After excluding the secondary causes of osteoporosis, was diagnosed with OJI and treated with bisphosphonates. During four years of follow-up, the column densitometry reflects a progressive increase in BMD from 0.25 to 0.77 g / cm2 and Z score of -4.9 to -0.1 standard deviations in his latest study. Our patient presented spectacular clinical and radiographic improvement when receiving zoledronic acid, which is why we suggest its use in this disease.


REFERENCES

  1. Folgueral M, Manuela Merino M, Alonso C, Sales C, González E. Osteoporosis idiopática juvenil: hallazgos radiológicos y revisión de la bibliografía. Radiología. 2005;47(5):287-290.

  2. Hoekman K, Papapoulos S, Peters A, Bijvoet O. Characteristics and Bisphosphonate Treatment of a Patient with Juvenile Osteoporosis. The Journal of Clinical Endocrinology & Metabolism. 1985;61(5):952-956.

  3. Imerci A, Canbek U, Haghari S, Sürer L, Kocak M. Idiopathic juvenile osteoporosis: A case report and review of the literature. 2017.

  4. Rauch F, Travers R, Norman M, Taylor A, Parfitt A, Glorieux F. Deficient Bone Formation in Idiopathic Juvenile Osteoporosis: A Histomorphometric Study of Cancellous Iliac Bone. Journal of Bone and Mineral Research. 2010;15(5):957- 963.

  5. Bacchetta J, Wesseling-Perry K, Gilsanz V, Gales B, Pereira R, Salusky I. Idiopathic juvenile osteoporosis: a cross-sectional single-center experience with bone histomorphometry and quantitative computed tomography. Pediatric Rheumatology. 2013;11(1):6.

  6. Khoshhal K. Childhood Osteoporosis. Journal of Taibah University Medical Sciences. 2011;6(2):61-76.

  7. Krassas G. Idiopathic Juvenil e Osteoporosis. Annals of the New York Academy of Sciences. 2006;900(1):409-412

  8. Smith R. idiopathic juvenile osteoporosis: experience of twenty-one patients. Rheumatology. 1995;34(1):68-77.

  9. Smith R. Idiopathic osteoporosis in the young. Journal of Pediatric Ortho paedics. 1981;1(2):237.

  10. K.L. Yam, G.M.S. Wong Idiopathic juvenile osteoporosis H. K. J. Paediatr 2004 (9), pp. 158-161

  11. Bartal E, Gage J. Idiopathic Juvenile Osteoporosis and Scoliosis. Journal of Pediatric Orthopaedics. 1982;2(3):295-299.

  12. Evans R, Dunstan C, Hills E. Bone metabolism in idiopathic juvenile osteoporosis: Acasereport. Calcified Tissue International. 1983;35(1):5-8.




2020     |     www.medigraphic.com