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Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2018, Number 3

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Rev Mex Patol Clin Med Lab 2018; 65 (3)

Detection of alloimmunization in patients with chronic renal failure and hemodialysis therapy

Nuñez-Torres D, Chiriboga-Ponce R

Language: Spanish
References: 22
Page: 145-149
PDF size: 291.40 Kb.


ABSTRACT

Introduction: Alloimmunization is a condition that usually occurs in patients whose pathology is affected by anemic conditions treated by blood transfusions, this condition can be avoid by the detection of irregular antibodies and the use of compatible blood components. Objective: Establish the frequency and type of circulating alloantibodies in patients diagnosed with chronic renal failure and hemodialysis therapy. Materials and methods: It was a descriptive study, probabilistic and relational. The screening of antibodies was carried out by using DiaPANEL ID panel cells on CARD LISS COOMBS ID card. For the analysis of results, we used the χ2 statistical test, the significance of the likelihood ratio and Fisher’s exact test, with a confidence interval of 95%. Results: A level of alloimmunization of 3.1% was detected, determining the presence of anti-E, anti-Lu (a), anti-A1 and 9.8% of autoantibodies in patients with previous transfusions, being the relationship statistically significant (p = 0.001). Conclusions: There is an alloimmunization in patients with chronic renal failure. The presence of an antibody related to the ABO system alerts the transfusion medicine services to make an identification of subgroups of A and included Rh phenotypes in order to obtain compatible blood products.


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