Pino BD, Sánchez SM, Marsán SV, Casado HI, Macias AC

Language: Spanish
References: 0
Page: 15-24
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ABSTRACT

Chronic lymphoid leukemia is the most common type of leukemia in Western countries, which most often affects males and the average age at diagnosis is 65 years. The most common form is the B-cell and is described in this article. LLC comprise a biologically distinct group of neoplasms characterized by proliferation and accumulation of small mature lymphocytes appearance in peripheral blood, bone marrow and tissues linfoides. Is the prototype of malignant disease involving defects programmed cell death or apoptosis. This disease may present variations in their immunophenotypic, clinical, cytogenetic and molecular characteristics. Approximately 80 % of patients with B-CLL have chromosomal abnormalities, mainly: deletions of chromosomes 11, 13, 6, 14 and 17. These last three are bad prognosis. The patients with CLL may have also immune dysfunctions responsible for immunodeficiency and autoimmunity. It is unknown the cause of CLL although initial reports suggest the involvement of Bcl-1 and Bcl-2 gene is why the current therapy is directed to inhibition of Bcl-2 as this is responsible in regulating apoptosis.