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2018, Number 2

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Rev Hematol Mex 2018; 19 (2)

Disorders of iron metabolism: Too little, too much, too late

Kahn MJ

Language: English
References: 11
Page: 73-76
PDF size: 273.85 Kb.


ABSTRACT

Elemental iron is essential for life and the biochemistry and physiology of iron balance and metabolism are now understood at the molecular level. Although iron deficiency remains a worldwide problem due to nutritional inadequacy, malabsorption, and blood loss, iron is often easily replaced. On the opposite end of the spectrum, mutations in genes responsible for normal iron hemostasis can result in hereditary hemochromatosis, a disease of iron overload. In this paper, the molecular biology of iron will be discussed in the context of human disease.


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