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2018, Number 4

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Dermatología Cosmética, Médica y Quirúrgica 2018; 16 (4)

Immunology of Alopecia Areata. Guardins of Immune Privilege (Part II)

Sánchez ÁI, González HWC, Ponce ORM

Language: Spanish
References: 24
Page: 300-305
PDF size: 161.28 Kb.


ABSTRACT

Alopecia areata is an autoimmune and autoinflammatory disease of unknown etiology. Natural protective factors of the hair follicle allow to continue with its normal cycle and offer immune privilege in anagen, this privilege can collapse and therefore trigger an autoimmune response like in alopecia areata. Many studies had described immune privilege guardians. This article highlights neuroendocrine factors and their important participation in the suppression of the major histocompatibility complex and the inhibition of proinflammatory cytokines and t lymphocites. Also the possible role and immunological impact of low serum vitamin d levels in patients with alopecia areata and other regulating factors that promote the ideal environment for the perpetuation of hair growth cycle.


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