Gutiérrez NR, Gutiérrez ABM

Language: Spanish
References: 0
Page: 1260-1279
PDF size: 267.05 Kb.

ABSTRACT

Fecundation is a complex and crucial process in human development. The interaction between the secondary oocyte and the spermatozoon transforms two differentiated cells into a totipotent zygote. Different proteins of the cell surface of both sex cells have been identified in the union and fusion of the gametes. The interaction begins with the adhesion of the spermatozoon to the zona pellucida. This binding is mediated by the SED-1 protein and / or the binding of galactosyl transferase (GalT-I), to the sugar chains of the zona pellucida (ZP3), which leads to the acrosome reaction. The knowledge of the molecules and the mechanisms responsible for these processes allows a better understanding of oocyte II - sperm interactions, which will allow the regulation of fertility and the development of new assisted reproduction methods solving infertility problems.