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>Journals >Gaceta Médica de México >Year 2019, Issue 1

Córdova-Gallardo J, Gómez-Toscano V, Dionicio-Avendaño AR, Jiménez-Escobar I
Tratamiento de infección crónica por virus de hepatitis C en niños, ¿perspectiva hacia la curación o lejos de la meta?
Gac Med Mex 2019; 155 (1)

Language: Español
References: 80
Page: 80-89
PDF: 263.62 Kb.

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Infection with hepatitis C virus is a global health problem; in Mexico, approximately 2% of the population is infected. In children, data on prevalence are variable according to the age group, but 0.1-2% of children are estimated to have chronic infection with hepatitis C virus, the main way of transmission of which is perinatal. Currently, there are direct-acting antiviral agents approved in adults that offer a sustained viral response rate higher than 95%; however, in children there are still only few studies confirming their safety and effectiveness. Although we are still far from the goal, we are rapidly advancing towards an optimal curative treatment also for pediatric patients.

Key words: Hepatitis C virus, Direct-acting antiviral agents, Sustained viral response.


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  82. A study to evaluate of hepatitis C virus infection in pediatric subjects (ZIRCON). EE. UU.: AbbVie; 2018.

  83. Abdel-Ghaffar TY. Treatment of Egyptian hepatitis C genotype 4 infected children (and adolescents) with combined sofosbuvir & daclatasvir. EE. UU.: Yassin Abdelghaffar Charity Center for Liver Disease and Research/Egyptian Cure Bank/Society of Friends of Liver Patients in the Arab World; 2018.

  84. Safety and efficacy of ledipasvir/sofosbuvir fixed dose combination +/- ribavirin in adolescents and children with chronic HCV-infection. EE. UU.: Gilead Sciences; 2018.

  85. Sofosbuvir/velpatasvir in adolescents and children with chronic HCV infection. EE. UU.: Gilead Sciences; 2018.

  86. Elbasvir (EBR)/grazoprevir (GZR) in pediatric participants with chronic hepatitis C infection (MK-5172-079). EE. UU.: Merck Sharp & Dohme Corp.; 2018.

  87. Efficacy and safety of ledipasvir/sofosbuvir fixed dose combination in the treatment of hepatitis C virus (HCV) infection in pediatric participants undergoing cancer chemotherapy (Egypt Peds). EE. UU.: Gilead Sciences; 2018.

  88. A study to evaluate the pharmacokinetics, safety, and efficacy of glecaprevir/ pibrentasvir in pediatric subjects with genotypes 1-6 chronic hepatitis C virus (HCV) infection (DORA). EE. UU.: AbbVie; 2018.

  89. Evaluation of daclatasvir (DCV) in combination with sofosbuvir (SOF) in children with chronic hepatitis C (CHC) infection. EE. UU.: Bristol-Myers Squibb; 2018.

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