2019, Number 2
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Rev Fac Med UNAM 2019; 62 (2)
Hemophagocytic syndrome. Case report and review of the literature
Dávila DD, De la Peña LIR
Language: Spanish
References: 8
Page: 15-21
PDF size: 304.72 Kb.
ABSTRACT
Hemophagocytic syndrome is a disease characterized by
fever, cytopenia, splenomegaly and other alterations in laboratories
due to excessive activation of macrophages, by
genetic mutations or secondary to infections, malignancy
or rheumatological diseases.
Because of the low specificity of the symptoms, the diagnosis
are usually late. Its management requires the treatment
of the underlying cause and, if necessary, medications that
decrease the inflammatory response.
REFERENCES
Weitzman S. Approach to Hemophagocytic Syndromes. Hematology. 2011.178-82.
Henter JI, Soder OO. Incidence and clinical features of familial hemophagocytic lymphohistiocytosis in Sweden. Acta Paediatr Scand 1991;80:428-35.
Henter JI, Horne AC. HLH-2004: Diagnostic and Therapeutic Guidelines for Hemophagocytic Lymphohistiocytosis. Pediatr Blood Cancer 2007;48:24-131.
Trottestam H. Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol. blood, 27 october 2011 _ volume 118, number 12
George MR. Hemophagocytic lymphohistiocytosis: review of etiologies and management. Journal of Blood Medicine. 2014;5:69-86
Fisman DN. Hemophagocytic syndromes and infection. Emerging Infectious Diseases. 2000;6(6):601-8.
Tamamyan GN, Kantarjian HM, Ning J. Malignancy-associated hemophagocytic lymphohistiocytosis in adults: Relation to hemophagocytosis, characteristics, and outcomes. Cancer. 2016;122:2857.
Trottestam H, Horne A, Aricò M. Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol. Blood. 2011;118:4577.
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