medigraphic.com
ISSN 1561-3119 (Electronic)

2019, Number 1

<< Back Next >>

Rev Cubana Pediatr 2019; 91 (1)

Colonization by environmental fungi in the uncontrolled respiratory allergic patient

Jiménez MM, Herrera BO, Rodríguez CJS, Paneque RI

Language: Spanish
References: 16
Page: 1-11
PDF size: 324.45 Kb.


ABSTRACT

Introduction: The presence of fungi in the respiratory tract can cause different allergic manifestations in sensitive persons.
Objective: To determine if fungi species isolated from the nasal mucosa of respiratory allergic patients can be defined as allergen-sensitive by means of skin tests.
Methods: Observational, prospective and cross-sectional study, where the overall sample consisted of all patients with a diagnosis of respiratory allergy or onset of decompensated variable bronchial asthma, over 2 years old and under 19 years old who attended to Allergy consultations in Havana, from January 2016 to January 2017. The sample obtained was 80 respiratory allergic patients.
Results: Of the total number of patients with symptoms of clinical asthma, rhinitis or both, Prick´s skin tests were obtained by fungal positive test in 52 of them (65 %) with a polysensitization in 24 (46.1 %). The most relevant cross reactivity occurred with the allergens of Aspergillus, Penicillium and Alternaria. The culture was positive in 54 nasal samples (67 %). The predominant fungal genus in allergic patients was Aspergillus in 70.3 % and within this Aspergillus fumigatus in 52.6 %.
Conclusions: The study of nasal mycobiota is a test that should be interpreted together with skin tests for the diagnosis of allergic diseases due to environmental fungi and it must be taken into account its importance for epidemiological control in fungal exposure.


REFERENCES

  1. Ragab A, Clement P, Vincken W, Nolard N, Simones F. Fungal cultures of different parts of the upper and lower airways in chronic rhinosinusitis. Rhinology. 2016;44:19-25.

  2. Rodrigues J, Caruthers C, Azmeh R, Dykewicz MS, Slavin RG, Knutsen AP. The spectrum of allergic fungal diseases of the upper and lower airways. Expert Rev ClinImmunol. 2016;12(5):531-50.

  3. Portnoy JM, Williams PB, Barnes CS. Innate Immune Responses to Fungal Allergens. Curr Allergy Asthma Rep. 2016;16(9):62.

  4. Fishwick D. New occupational and environmental causes of asthma and extrinsic allergic alveolitis. Clin Chest Med. 2012;33:605-16.

  5. Patterson K, Strek ME. Allergic bronchopulmonaryaspergillosis. Proc Am Thorac Soc. 2014;7:237-44.

  6. Hoyt AE, Borish L, Gurrola J, Payne S. Allergic Fungal Rhinosinusitis. J Allergy ClinImmunolPract. 2016;4(4):599-604.

  7. Twaroch TE, Curin M, Valenta R, Swoboda I. Mold allergens in respiratory allergy: from structure to therapy. Allergy Asthma Immunol Res. 2015;7(3):205-20.

  8. Fokkens W y Cols European Position Paper on Rhinosinusitis and Nasal Polyps. Rhinology. 2013;45(suppl. 20):1-139.

  9. Denning DW, Pleuvry A, Cole DC. Global burden of Allergic bronchopulmonaryaspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults. Med Micol. 2014;51:361-70.

  10. Venero Fernández Silvia Josefina, Varona Pérez Patricia, Fabret Ortiz Dania, Suárez Medina Ramón, Bonet Gorbea Mariano, Molina Esquivel Enrique et al. Asma bronquial y rinitis en escolares de Ciudad de La Habana (2001 a 2002). Rev Cubana Hig Epidemiol 2009;47(1). Acceso: 28/10/2018. Disponible en: http://scielo.sld.cu/scielo.php? script=sci_arttext&pid=S1561-30032009000100005&lng=es.

  11. Díaz Rodríguez A, Fabré Ortiz DE, Coutin Marie G, González Méndez T. La sensibilización a hongos ambientales y su relación con enfermedades atópicas en escolares. Rev Cubana Med Gen Integr. 2010;26(4):647-55. Acceso: 13/10/2018. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864- 21252010000400007&lng=es

  12. Fukutomi Y, Taniguchi M. Sensitization to fungal allergens: Resolved and unresolved issues. AllergolInt. 2015;64(4):321-31.

  13. Rojas TI, Martínez E, Aíra MJ, Almaguer M. Aeromicota de ambientes internos: Comparación de métodos de muestreo. Bol Micol.2008; 23:67-73.

  14. Oliveira M, Caramalho R. Aspergillus fumigatus: a mere airborne particle or a powerful biohazard? Nova Acta Científica Compostelana (Bioloxía). 2014;(21):57-64.

  15. Sellart-Altisent M, Torres-Rodríguez JM, Gómez de Ana S, Alvarado-Ramírez E. Microbiota fúngica nasal en sujetos alérgicos y sanos Rev Iber Micol. 2017;24:125-30.

  16. Ministerio de Salud Pública. Anuario estadístico de salud. Cuba. La Habana: Ministerio; 2014.




2020     |     www.medigraphic.com