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Federación Mexicana de Ginecología y Obstetricia, A.C.

2019, Number 02

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Ginecol Obstet Mex 2019; 87 (02)

Topical vaginal estrogen and vaginal vault dehiscence in patients rather than a laparoscopic total hysterectomy

Morgan-Ortiz F, Sosa-Atondo DG, Morgan-Ruiz FV, Soto-Pineda JM, Báez-Barraza J, Peraza-Garay FJ

Language: Spanish
References: 23
Page: 93-99
PDF size: 215.27 Kb.


ABSTRACT

Objective: To compare the frequency of vaginal cuff dehiscence in patients managed with and without conjugated equine estrogens vaginally prior to total laparoscopic hysterectomy (TLH).
Materials and Methods: In a single-blind controlled clinical trial, 236 patients with indications for laparoscopic total hysterectomy for benign pathology at the Hospital Civil de Culiacán and who agreed to participate in the study were randomly assigned to receive vaginally conjugated equine estrogens (study group) or vaginal lubricating cream as a placebo (control group) for 3 weeks prior to the procedure. Patients with diabetes mellitus, treated with steroids and history of a recent thromboembolic event were excluded. The frequency of vaginal cuff dehiscence was evaluated at 7 and 30 days after surgery. The student's t-test was used to compare means and the Chi-square test was used to compare proportions, with relative risk (RR) calculation to evaluate the risk of vaginal cuff dehiscence.
Results: We studied 236 patients with average age, in both groups, 47.1 and 47.7 years, respectively (p › .05). The mean age of the patients was similar between the groups (47.1 vs 47.7 years, p›.05). The gynecological-obstetric history and indications for hysterectomy were similar between both groups (p = .340). The incidence of vaginal cuff dehiscence was 2.5% (n = 3) in the group treated with conjugated equine estrogens vaginally and 6.8% (n = 8) in the patients of thse group treated with vaginal lubricant (p= .123; RM= .359; IC95%: .093-1.387).
Conclusions: The risk of presenting vaginal cuff dehiscence was similar between the group of lubricant and topical vaginal estrogens, but with a lower tendency in the frequency of vaginal cuff dehiscence in the group of topical estrogens.


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