2019, Number 1
Rev Latin Infect Pediatr 2019; 32 (1)
Epidemiological profile of viral pneumonia through the use of molecular tests in a third level hospital in Mexico: five years of experience
Fortes GS, Hernández PM, Castillo BJI, Cravioto QP, González SN
PDF size: 185.21 Kb.
The World Health Organization estimates 156 million cases of community-acquired pneumonia (CAP) per year; in 70% of the cases, the etiology is viral. The aim of this study is to describe the epidemiology of viral pneumonia in a tertiary hospital in Mexico. Material and methods:
Observational, descriptive and retrospective study from 2012 to 2016. We included 183 patients with a clinical diagnosis of viral pneumonia and a positive polymerase chain reaction (PCR) during their hospitalization. Results:
The mean age of the patients was 21 ± 6 months; 57% were males. Respiratory viruses were reported in the following order: rhinovirus/enterovirus 37.7%, RSV 19%, metapneumovirus 14.8% and seasonal influenza (H1N1, H3N2, B) 14.8%, mainly; rhinovirus/enterovirus (62%) and RSV (30%) were associated with coinfection. Conclusion:
The study determined the etiology and frequency of the main viral agents detected by PCR in a referral center in Mexico, and the viral coinfections and seasonality as well. The use of molecular tests must be mandatory in order to perform prospective studies on a larger scale.
Jadavji T, Law B, Lebel MH et al. A practical guide for the diagnosis and treatment of pediatric pneumonia. CMAJ. 1997; 156: S703.
Rudan I, Boschi-Pinto C, Biloglav Z et al. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ. 2008; 86: 408.
Jain S. Epidemiology of viral pneumonia. Clin Chest Med. 2017; 38 (1): 1-9.
Jain S, Williams DJ, Arnold SR, Ampofo K, Bramley AM, Reed C et al. Community-acquired pneumonia requiring hospitalization among U.S. children. N Engl J Med. 2015; 372 (9): 835-845.
WHO. World Health Statistics 2014. En: Data WLCiP, editor. Global health Indicators. Switzerland: World Health Organization; 2014.
Wong RM, Garcia ML, Noyola D et al. Respiratory viruses detected in Mexican children younger than 5 years old with community-acquired pneumonia: a national multicenter study. International Journal of Infectious Disease. 2017; 62: 32-38.
Wong-Chew RM, Farfan-Quiroz R, Sanchez-Huerta JL, Nava-Frias M, Casasola-Flores J, Santos-Preciado JI. Frequency of respiratory viruses and clinical characteristics in children attending a care center in Mexico City. Salud Pública Mex. 2010; 52 (6): 528-532.
Self WH, Williams DJ, Zhu Y, Ampofo K, Pavia AT, Chappell JD et al. Respiratory viral detection in children and adults: comparing asymptomatic controls and patients with community-acquired pneumonia. J Infect Dis. 2016; 213 (4): 584-591.
Wilson J, Rowlands K, Rockett K et al. Genetic variation at the IL10 gene locus is associated with severity of respiratory syncytial virus bronchiolitis. J Infect Dis. 2005; 191: 1705.
Crowe JE Jr, Williams JV. Immunology of viral respiratory tract infection in infancy. Paediatr Respir Rev. 2003; 4: 112.
Zhang L, Bukreyev A, Thompson CI et al. Infection of ciliated cells by human parainfluenza virus type 3 in an in vitro model of human airway epithelium. J Virol. 2005; 79: 1113.
Ottolini MG, Hemming VG, Piazza FM et al. Topical immunoglobulin is an effective therapy for parainfluenza type 3 in a cotton rat model. J Infect Dis. 1995; 172: 243.