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Revista de Sanidad Militar

ISSN 0301-696X (Print)
Órgano de difusión del Servicio de Sanidad Militar y del Colegio Nacional de Médicos Militares
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2018, Number 5-6

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Rev Sanid Milit Mex 2018; 72 (5-6)

In vitro fertilization: Louise Brown, four decades after her birth

Mata-Miranda MM, Vázquez-Zapién GJ
Full text How to cite this article

Language: Spanish
References: 6
Page: 363-365
PDF size: 195.79 Kb.


Key words:

In vitro fertilization, embryo transfer, assisted fertilization, Louise Brown.

ABSTRACT

Forty years ago, Patrick Steptoe, Robert Edwards, and Jean Purdy achieved the first human birth through in vitro fertilization (IVF). IVF is one of the transformative technologies of the 20th century, designed to help human conception, and involves four aspects: 1. Acquisition of a sufficient number of mitotic and cytoplasmically mature oocyte. 2. In vitro fertlization of these mature oocytes; 3. Embryo culture before implantation; 4. Embryo transfer within the maternal womb. The story of the collaboration of Steptoe and Edwards was full of disappointment and failure, reaching a successful conclusion with the birth of a girl named Louise Brown, after 102 failed embryo transfers. Due to this success, Robert Edwards, in 2010, received the Nobel Prize in Physiology or Medicine for the development of IVF plus embryo transfer (IVF / ET). His work resulted in the birth of the first «test tube baby» in July 1978. Now, more than four million babies have born using IVF / ET, and a medical speciallity called Biology of Reproduction has been created, which is responsible of the assisted fertilization.


REFERENCES

  1. Biggers JD. IVF and embryo transfer: historical origin and development. Reprod Biomed Online. 2012; 25 (2): 118-127.

  2. Bergua JB. Historia de las religiones. España: Clásicos Bergua; 1964.

  3. Shah SM, Chauhan MS. Cap. 12. Embryo transfer technology. En: Reproduction in Buffalo: natural and assisted reproductive techniques. Notion Press; 2017.

  4. Rao KA. Principles & practice of assisted reproductive technology. Vol. 1. India: Jaypee Brothers Medical Publishers; 2014.

  5. Brinsden PR. Thirty years of IVF: the legacy of Patrick Steptoe and Robert Edwards. Hum Fertil (Camb). 2009; 12 (3): 137-143.

  6. Kamel RM. Assisted reproductive technology after the birth of Louise Brown. J Reprod Infertil. 2013; 14 (3): 96-109.




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Rev Sanid Milit Mex. 2018;72