medigraphic.com
Federación Mexicana de Ginecología y Obstetricia, A.C.

2019, Number 05

<< Back Next >>

Ginecol Obstet Mex 2019; 87 (05)

Relationship between uric acid and body composition, metabolic profile, leptin and adiponectin in postmenopausal women

Saucedo R, Peña-Cano MI, Valencia J, Morales-Ávila E, Zavala-Moha JA, López A, Hernández-Valencia M

Language: Spanish
References: 33
Page: 311-318
PDF size: 289.46 Kb.


ABSTRACT

Objective: To determine the relation between uric acid and metabolic and anthropometric parameters and adipokines leptin and adiponectin in post-menopausal women.
Materials and Methods: A descriptive cross-sectional study was performed in post-menopausal women. Anthropometric measurements were taken by electric bioimpedance, and fasting venous blood samples were taken to determine glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides by enzyme techniques, and levels of adiponectin, leptin and insulin were measured by radioimmunoassay. Insulin resistance was calculated using HOMA-IR. The variables were described with mean and standard deviation. Statistical analysis was performed by Pearson correlation test to evaluate the relation between uric acid and the study variables, and a multiple regression was performed to determine the parameters with greatest influence on uric acid.
Results: The study included 90 post-menopausal women aged 55 to 84 years. The average age of the participants was 63.7 years, and the average concentration of uric acid was 4.9 mg/dL. In bivariate analysis, anthropometric parameters, LDL-cholesterol, triglycerides and leptin showed positive association with uric acid, and HDL-cholesterol and adiponectin had a negative one. In multiple regression analysis, body fat associated with uric acid independent of body weight (beta=0.592, p=0.037).
Conclusions: Uric acid relates with an adverse cardio-metabolic profile in postmenopausal women.


REFERENCES

  1. Wu XW, et al. Urate oxidase: primary structure and evolutionary implications. Proc Natl Acad Sci USA 1989;86(23):9412- 16. https://doi.org/10.1073/pnas.86.23.9412

  2. Prado de Oliveira E, Burini RC. High plasma uric acid concentration: causes and consequences. Diabetol Metab Syndr 2012;4:12. https://doi.org/10.1186/1758-5996-4-12

  3. Johnson RJ, et al. Uric acid, evolution and primitive cultures. Semin Nephrol 2005;25(1):3-8. https://doi. org/10.1016/j.semnephrol.2004.09.002

  4. Martinon F. Mechanisms of uric acid crystal-mediated autoinflammation. Immunol Rev 2010; 233(1):218-32. https:// doi.org/10.1111/j.0105-2896.2009.00860.x

  5. Coutinho Tde A, et al. Associations of serum uric acid with markers of inflammation, metabolic syndrome, and subclinical coronary atherosclerosis. Am J Hypertens 2007;20(1):83-9. https://doi.org/10.1016/j.amjhyper. 2006.06.015

  6. Levine W, et al. Serum uric acid and 11.5-year mortality of middle-aged women: findings of the Chicago Heart Association Detection Project in Industry. J Clin Epidemiol 1989;42(3):257-67. https://doi.org/10.1016/0895- 4356(89)90061-9

  7. Wingrove CS, et al. The effect of menopause on serum uric acid levels in non-obese healthy women. Metabolism 1998;47(4):435-8. https://doi.org/10.1016/S0026- 0495(98)90056-7

  8. Ioannou GN, Boyko EJ. Effects of menopause and hormone replacement therapy on the associations of hyperuricemia with mortality. Atherosclerosis 2013;226(1):220-7. https:// doi.org/10.1016/j.atherosclerosis.2012.10.044

  9. Díaz-Martínez AG, et al. Evaluación del tejido adiposo visceral y de la concentración de lípidos en mujeres pre y posmenopáusicas. Ginecol Obstet Mex 2016;84(5):294-300.

  10. Matsuura F, et al. Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity. Metabolism 1998;47(8): 929-33. https://doi.org/10.1016/S0026-0495(98)90346-8

  11. Facchini F, et al. Relationship between resistance to insulin mediated glucose uptake, urinary uric acid clearance and plasma uric acid concentration. JAMA 1991;266(21):3008- 11. doi:10.1001/jama.1991.03470210076036

  12. Quiñones Galvan A, et al. Effect of insulin on uric acid excretion in humans. Am J Physiol 1995;268(1):E1-E5. https:// doi.org/10.1152/ajpendo.1995.268.1.E1

  13. Matthews DR, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28(7):412-9.

  14. Zárate A, Saucedo R, Basurto L, Martínez C. La enfermedad cardiovascular como amenaza actual para la mujer adulta mayor. La relación con los estrógenos. Ginecol Obstet Mex 2007;75(5):286-92.

  15. Wang Q, et al. Metabolic characterization of menopause: cross-sectional and longitudinal evidence. BMC Med 2018;16(1):17. https://doi.org/10.1186/s12916-018- 1008-8

  16. González-Chávez A, Elizondo-Argueta S, Amancio-Chassin O. Relación entre síndrome metabólico e hiperuricemia en población aparentemente sana. Rev Med Hosp Gen Méx 2011;74(3):132-7.

  17. Emmerson BT. The management of gout. N Engl J Med 1996;334(7):445-51. doi: 10.1056/NEJM199602153340707

  18. Fam AG. Gout, diet, and the insulin resistance syndrome. J Rheumatol 2002;29(7): 1350-5.

  19. Tsushima Y, et al. Uric acid secretion from adipose tissue and its increase in obesity. J Biol Chem 2013;288(38):27138- 49. doi: 10.1074/jbc.M113.485094.

  20. Glynn RJ, Campion EW, Silbert JE. Trends in serum uric acid levels 1961-1980. Arthritis Rheum 1983;26(1):87-93.

  21. Nakanishi N, et al. Predictors for development of hyperuricemia: an 8-year longitudinal study in middle-aged Japanese men. Metabolism 2001;50(6):621-6. https:// doi.org/10.1053/meta.2001.24196

  22. Nakagawa T, et al. A causal role for uric acid in fructoseinduced metabolic syndrome. Am J Physiol Renal Physiol 2006;290(3):F625-31. https://doi.org/10.1152/ajprenal. 00140.2005

  23. Cheung, KJ, et al. Xanthine oxidoreductase is a regulator of adipogenesis and PPARg activity. Cell Metab 2007;5(2):115- 28. https://doi.org/10.1016/j.cmet.2007.01.005

  24. Masuo K, et al. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension 2003;42(4):474-80. https://doi.org/10.1161/01.HYP.0000091371.53502.D3

  25. Lyngdoh T, et al. Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach. PLoS One 2012;7(6):e39321. https://doi. org/10.1371/journal.pone.0039321

  26. Matsubara K, et al. Relationship between hypertriglyceridemia and uric acid production in primary gout. Metabolism 1989;38(7):698-701. https://doi.org/10.1016/0026- 0495(89)90110-8

  27. Kim TH, et al. The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus. Diabetol Metab Syndr 2012;4(1):3. https://doi.org/10.1186/1758-5996-4-3

  28. Bedir A, et al. Leptin might be a regulator of serum uric acid concentrations in humans. Jpn Heart J 2003;44(4):527- 36. https://doi.org/10.1536/jhj.44.527

  29. Matsubara M, et al. Elevated serum leptin concentrations in women with hyperuricemia. J Atheroscler Thromb 2002;9(1):28-34. https://doi.org/10.5551/jat.9.28

  30. Park JS, et al. Relationships between serum uric acid, adiponectin and arterial stiffness in postmenopausal women. Maturitas 2012;73(4):344-8. https://doi.org/10.1016/j. maturitas.2012.09.009

  31. Defronzo RA, et al. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237(3):214-23. https://doi.org/10.1152/ ajpendo.1979.237.3.E214

  32. Hernández ÁM, et al. Encuesta Nacional de Salud y Nutrición de Medio Camino 2016. Cuernavaca, México: Instituto Nacional de Salud Pública;2016. https://www.gob.mx/cms/ uploads/attachment/file/209093/ENSANUT.pdf

  33. Freedman DS, et al. Relation of serum uric acid to mortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol 1995;141(7):637-44. https://doi.org/10.1093/oxfordjournals.aje.a117479




2020     |     www.medigraphic.com