2019, Number 1
Frequency of transmissible infectious agents in blood donors at CMN 20 de Noviembre ISSSTE, Mexico
Navarrete‑Castro J, Siria‑Torreblanca N, González‑Avante M, Navarrete‑Castro R
Language: Spanish
References: 8
Page: 12-18
PDF size: 141.97 Kb.
ABSTRACT
Background: Hemotherapy is a clinical success. The Official Mexican Standard NOM-253-SSA1-2012 will be responsible for mandatory diagnostic tests on blood donors. Methods: Retrospective study. The results of diagnostic screening tests established in NOM-253-SSA1-2012 were included. The analytical phase included equipment: ARCHITECT (Abbott) based on chemiluminiscent microparticle immunoassay (CMIA) and TIGRIS (Amplicor) with a nucleic acid amplification test (NAT); Brucella by plaque agglutination. We performed a simple frequency statistical analysis, Z test statistics for method comparison and Bayesian analysis for diagnostic probabilities. Results: Of 36,793 donors studied, 1.75% (643) was reactive, syphilis more frequently 0.66% (243); VHC with 0.49% (180), Chagas 0.17% (64), VIH 0.18% (67), VHB 0.11% (42) and Brucella with 0.13% (47). Using NAT 0.14% (52) were reactive; VIH 0.049% (18), VHC 0.060% (22), VHB 0.033% (12) and in Coinfection of VIH + HVB 0.008% (3); in the comparison of VHC-only methods it was statistically significant (95% CI, p ‹ 0.05). In the Bayesian analysis: CMIA presented a diagnostic accuracy (ED) of 0.81 (VHC), 0.90 (VHB) and 0.73 (VIH); for NAT an ED of 1.0 (VHC), 1.0 (VHB) and 0.97 (VIH) respectively. Conclusion: Our frequency coincides with literature reports; VHC alone was statistically significant (comparison of methods). The diagnostic accuracy for VHC, VHB and VIH by CMIA and NAT was high. (Bayesian analysis).REFERENCES