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Órgano oficial de la Asociación Mexicana de Medicina Transfusional A.C.

2019, Number 1

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Rev Mex Med Transfus 2019; 12 (1)

Frequency of transmissible infectious agents in blood donors at CMN 20 de Noviembre ISSSTE, Mexico

Navarrete‑Castro J, Siria‑Torreblanca N,  González‑Avante M,  Navarrete‑Castro R

Language: Spanish
References: 8
Page: 12-18
PDF size: 141.97 Kb.


ABSTRACT

Background: Hemotherapy is a clinical success. The Official Mexican Standard NOM-253-SSA1-2012 will be responsible for mandatory diagnostic tests on blood donors. Methods: Retrospective study. The results of diagnostic screening tests established in NOM-253-SSA1-2012 were included. The analytical phase included equipment: ARCHITECT (Abbott) based on chemiluminiscent microparticle immunoassay (CMIA) and TIGRIS (Amplicor) with a nucleic acid amplification test (NAT); Brucella by plaque agglutination. We performed a simple frequency statistical analysis, Z test statistics for method comparison and Bayesian analysis for diagnostic probabilities. Results: Of 36,793 donors studied, 1.75% (643) was reactive, syphilis more frequently 0.66% (243); VHC with 0.49% (180), Chagas 0.17% (64), VIH 0.18% (67), VHB 0.11% (42) and Brucella with 0.13% (47). Using NAT 0.14% (52) were reactive; VIH 0.049% (18), VHC 0.060% (22), VHB 0.033% (12) and in Coinfection of VIH + HVB 0.008% (3); in the comparison of VHC-only methods it was statistically significant (95% CI, p ‹ 0.05). In the Bayesian analysis: CMIA presented a diagnostic accuracy (ED) of 0.81 (VHC), 0.90 (VHB) and 0.73 (VIH); for NAT an ED of 1.0 (VHC), 1.0 (VHB) and 0.97 (VIH) respectively. Conclusion: Our frequency coincides with literature reports; VHC alone was statistically significant (comparison of methods). The diagnostic accuracy for VHC, VHB and VIH by CMIA and NAT was high. (Bayesian analysis).


REFERENCES

  1. NORMA Oficial Mexicana NOM-253-SSA1-2012, Para la disposición de sangre humana y sus componentes con fines terapéuticos.

  2. Schmuñis GA, Zicker F, Segura EL, Del Pozo AE. Transfusion-transmitted infectious diseases in Argentina, 1995 through 1997. Transfusion. 2000; 40 (9): 1048-1053.

  3. WHO. Blood safety and availability. Fact sheet No 279. Reviewed June 2015.

  4. World Health Organization. Department of Reproductive Health and Research. The global elimination of congenital syphilis: rationale and strategy for action. Geneva; 2007.

  5. World Health Organization. Reporte del VI grupo de trabajo científico de la OMS sobre la enfermedad de Chagas. Ginebra; 2007.

  6. Bedoya JA, Cortés-Márquez MM, Cardona-Arias JA. Seroprevalencia de marcadores de infecciones transmisibles por vía transfusional en banco de sangre de Colombia. Rev Saúde Pública. 2012; 46 (6): 950-959.

  7. Robles-Martínez AK, Becerra-Leyva MG, Licon-González GE. Seroprevalencia de marcadores infecciosos en los servicios de medicina transfusional públicos e instituciones del estado de Jalisco durante 2014. Rev Mex Med Tran. 2015; 8 (Supl 1): S15.

  8. Rawat A, Diwaker P, Gogoi P, Singh B. Seroprevalence & changing trends of transfusion-transmitted infections amongst blood donors in a Regional Blood Transfusion Centre in north India. Indian J Med Res. 2017; 146 (5): 642-645.




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